| Plasma GH responses to GHRH and insulin-induced hypoglycemia in man. | |
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MedLine Citation:
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PMID: 3923025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in plasma GH levels in response to an intravenous bolus injection of 200 micrograms GHRH-44 or 0.1 U/kg body weight regular insulin were examined in normal men who were pre-treated with 200 micrograms GHRH-44 or 0.1 U/kg body weight regular insulin 120 min in advance. The prior bolus injection of GHRH-44 inhibited the plasma GH response to the subsequent administration of GHRH-44 whereas the plasma GH response to the subsequent injection of insulin was not influenced by the prior administration of GHRH-44. The prior administration of insulin attenuated the plasma GH response to the subsequently given GHRH-44. These results suggest that desensitization of GHRH receptors in somatotrophs and/or somatostatin hypersecretion induced by increase in plasma GH levels following the prior GHRH-44 administration may be involved in the mechanism by which the prior GHRH-44 administration or insulin-induced hypoglycemia suppressed plasma GH responses to the following GHRH-44 administration. Sudden suppression of somatostatin secretion, which causes rebound of GH secretion, may occur in insulin-induced hypoglycemia. |
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Authors:
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T Shibasaki; M Hotta; A Masuda; T Imaki; N Obara; H Demura; N Ling; K Shizume |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 60 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1985 Jun |
Date Detail:
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Created Date: 1985-06-24 Completed Date: 1985-06-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1265-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chemical Phenomena Chemistry Dose-Response Relationship, Drug Growth Hormone / blood* Growth Hormone-Releasing Hormone / administration & dosage* Humans Hypoglycemia / blood, chemically induced* Insulin / pharmacology* Male |
| Grant Support | |
ID/Acronym/Agency:
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AM18811/AM/NIADDK NIH HHS; HD09690/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 9002-72-6/Growth Hormone; 9034-39-3/Growth Hormone-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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