| Plasma GABA predicts acute response to divalproex in mania. | |
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MedLine Citation:
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PMID: 8645774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bipolar I, manic phase inpatients were treated with divalproex sodium, lithium, or placebo in a previously reported parallel group multicenter, double-blind, randomized, controlled acute phase treatment trial. Plasma concentrations of gamma aminobutyric acid (GABA) were measured before and after treatment. Higher pretreatment plasma GABA levels were significantly (p = .04) related to a better clinical response to divalproex (n = 19). Pretreatment plasma GABA levels did not correlate with response to either lithium (n = 13) or placebo (n = 31). Following treatment with divalproex sodium, plasma GABA levels decreased significantly (p < .05), compared to placebo. Pretreatment plasma GABA levels were not related to overall severity of manic symptoms. Plasma GABA may predict response to pharmacologic agents acting on the GABA system. |
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Authors:
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F Petty; A J Rush; J M Davis; J R Calabrese; S E Kimmel; G L Kramer; J G Small; M J Miller; A E Swann; P J Orsulak; M E Blake; C L Bowden |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biological psychiatry Volume: 39 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-07-19 Completed Date: 1996-07-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 278-84 Citation Subset: IM |
Affiliation:
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Veterans Affairs Medical Center, Dallas, TX 75216, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antimanic Agents / adverse effects, therapeutic use* Bipolar Disorder / blood, drug therapy* Double-Blind Method Female Humans Lithium Carbonate / adverse effects, therapeutic use Male Middle Aged Treatment Outcome Valproic Acid / adverse effects, therapeutic use* gamma-Aminobutyric Acid / blood* |
| Grant Support | |
ID/Acronym/Agency:
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MH37899/MH/NIMH NIH HHS; MH41115/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antimanic Agents; 554-13-2/Lithium Carbonate; 56-12-2/gamma-Aminobutyric Acid; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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