Document Detail

Plasma GABA predicts acute response to divalproex in mania.
MedLine Citation:
PMID:  8645774     Owner:  NLM     Status:  MEDLINE    
Bipolar I, manic phase inpatients were treated with divalproex sodium, lithium, or placebo in a previously reported parallel group multicenter, double-blind, randomized, controlled acute phase treatment trial. Plasma concentrations of gamma aminobutyric acid (GABA) were measured before and after treatment. Higher pretreatment plasma GABA levels were significantly (p = .04) related to a better clinical response to divalproex (n = 19). Pretreatment plasma GABA levels did not correlate with response to either lithium (n = 13) or placebo (n = 31). Following treatment with divalproex sodium, plasma GABA levels decreased significantly (p < .05), compared to placebo. Pretreatment plasma GABA levels were not related to overall severity of manic symptoms. Plasma GABA may predict response to pharmacologic agents acting on the GABA system.
F Petty; A J Rush; J M Davis; J R Calabrese; S E Kimmel; G L Kramer; J G Small; M J Miller; A E Swann; P J Orsulak; M E Blake; C L Bowden
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  39     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-07-19     Completed Date:  1996-07-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  278-84     Citation Subset:  IM    
Veterans Affairs Medical Center, Dallas, TX 75216, USA.
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MeSH Terms
Antimanic Agents / adverse effects,  therapeutic use*
Bipolar Disorder / blood,  drug therapy*
Double-Blind Method
Lithium Carbonate / adverse effects,  therapeutic use
Middle Aged
Treatment Outcome
Valproic Acid / adverse effects,  therapeutic use*
gamma-Aminobutyric Acid / blood*
Grant Support
Reg. No./Substance:
0/Antimanic Agents; 554-13-2/Lithium Carbonate; 56-12-2/gamma-Aminobutyric Acid; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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