Document Detail

Plasma nociceptin/orphanin FQ levels rise after spontaneous episodes of angina, but not during induced myocardial ischemia.
MedLine Citation:
PMID:  19560501     Owner:  NLM     Status:  MEDLINE    
The aim of our study was to evaluate the effects of repeated episodes of angina and induced myocardial ischemia on plasma nociceptin/orphanin FQ (N/OFQ) levels. Patients with unstable angina (23 with new onset severe angina or accelerated angina and 18 with subacute angina at rest) who had had repeated spontaneous episodes of chest pain in the last week before the study underwent myocardial perfusion single-photon emission computed tomography using adenosine infusion. Twenty subjects without clinical symptoms of angina matched for age, sex and cardiac risk factors served as a control group. N/OFQ levels were significantly (P<0.01) higher in the patients (15.2+/-2.1 pg/ml) than in the control group (8.5+/-2.6 pg/ml). Blood pressure and heart rate did not significantly differ. All patients showed transient adenosine infusion myocardial ischemia that did not induce chest pain or significantly modify plasma N/OFQ levels or hemodynamic parameters. Our findings show that unstable angina is associated with a significant increase in circulating N/OFQ levels unrelated to intervening transient myocardial ischemia or hemodynamic changes. This increase is probably related to the chest pain repeatedly occurring in the course of coronary artery disease, but absent during transient adenosine-induced myocardial ischemia.
Fiorella Fontana; Pasquale Bernardi; Carmine Pizzi; Santi Spampinato; Andrea Bedini; Emilio Merlo Pich
Publication Detail:
Type:  Journal Article     Date:  2009-06-26
Journal Detail:
Title:  Peptides     Volume:  30     ISSN:  1873-5169     ISO Abbreviation:  Peptides     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-05     Completed Date:  2009-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1705-9     Citation Subset:  IM    
Dipartimento di Medicina Interna, dell'Invecchiamento e Malattie Nefrologiche, Ospedale S. Orsola, Via Massarenti 9, Bologna, Italy.
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MeSH Terms
Adenosine / pharmacology
Angina, Unstable / blood*
Blood Pressure / drug effects
Heart Rate / drug effects
Middle Aged
Myocardial Ischemia / blood*,  chemically induced*
Myocardial Perfusion Imaging
Opioid Peptides / blood*
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Opioid Peptides; 0/nociceptin; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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