Document Detail

Plasma endothelin-1 and vascular endothelial growth factor levels and their relationship to hemodynamics in idiopathic pulmonary fibrosis.
MedLine Citation:
PMID:  22869459     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pulmonary hypertension (PH) is associated with a poor prognosis in idiopathic pulmonary fibrosis (IPF). Endothelin-1 (ET-1) and vascular endothelial growth factor (VEGF) are important in both fibrosis and vascular remodeling.
OBJECTIVES: We sought to determine the relationship between ET-1 and VEGF levels and hemodynamics in patients with IPF. We hypothesized that higher levels of ET-1 and VEGF would be associated with higher pulmonary artery pressures (PAP) and pulmonary vascular resistance (PVR) in patients with IPF.
METHODS: We performed a cross-sectional analysis of 52 adults with IPF enrolled in a prospective cohort with available clinical data, platelet-free plasma, and hemodynamics. ET-1 and VEGF levels were measured via immunoassay. The associations of ET-1 and VEGF with PAP and PVR were examined using generalized additive models adjusted for age, gender, race/ethnicity, and forced vital capacity (% predicted).
RESULTS: Sixteen of 52 (30.8%) had PH (mean PAP ≥25 mm Hg). After multivariable adjustment, higher ET-1 levels were significantly associated with higher systolic (p = 0.01), diastolic (p = 0.02), and mean (p = 0.01) PAP and possibly higher PVR (p = 0.09). There were no significant associations between VEGF levels and hemodynamics.
CONCLUSIONS: Higher levels of ET-1 were associated with higher PAP and possibly higher PVR in participants with IPF. In a subgroup of patients, ET-1 may be a contributor to pulmonary vascular disease burden in IPF.
Corey E Ventetuolo; Steven M Kawut; David J Lederer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-03
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  84     ISSN:  1423-0356     ISO Abbreviation:  Respiration     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-28     Completed Date:  2013-03-11     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  299-305     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
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MeSH Terms
Arterial Pressure
Cross-Sectional Studies
Endothelin-1 / metabolism*
Hypertension, Pulmonary / etiology,  metabolism*
Idiopathic Pulmonary Fibrosis / complications,  metabolism*
Middle Aged
Prospective Studies
Pulmonary Artery / physiopathology*
Vascular Endothelial Growth Factor A / metabolism*
Vascular Resistance
Grant Support
Reg. No./Substance:
0/Endothelin-1; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A

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