| Plasma endothelin-1 and vascular endothelial growth factor levels and their relationship to hemodynamics in idiopathic pulmonary fibrosis. | |
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MedLine Citation:
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PMID: 22869459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pulmonary hypertension (PH) is associated with a poor prognosis in idiopathic pulmonary fibrosis (IPF). Endothelin-1 (ET-1) and vascular endothelial growth factor (VEGF) are important in both fibrosis and vascular remodeling. OBJECTIVES: We sought to determine the relationship between ET-1 and VEGF levels and hemodynamics in patients with IPF. We hypothesized that higher levels of ET-1 and VEGF would be associated with higher pulmonary artery pressures (PAP) and pulmonary vascular resistance (PVR) in patients with IPF. METHODS: We performed a cross-sectional analysis of 52 adults with IPF enrolled in a prospective cohort with available clinical data, platelet-free plasma, and hemodynamics. ET-1 and VEGF levels were measured via immunoassay. The associations of ET-1 and VEGF with PAP and PVR were examined using generalized additive models adjusted for age, gender, race/ethnicity, and forced vital capacity (% predicted). RESULTS: Sixteen of 52 (30.8%) had PH (mean PAP ≥25 mm Hg). After multivariable adjustment, higher ET-1 levels were significantly associated with higher systolic (p = 0.01), diastolic (p = 0.02), and mean (p = 0.01) PAP and possibly higher PVR (p = 0.09). There were no significant associations between VEGF levels and hemodynamics. CONCLUSIONS: Higher levels of ET-1 were associated with higher PAP and possibly higher PVR in participants with IPF. In a subgroup of patients, ET-1 may be a contributor to pulmonary vascular disease burden in IPF. |
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Authors:
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Corey E Ventetuolo; Steven M Kawut; David J Lederer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-08-03 |
Journal Detail:
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Title: Respiration; international review of thoracic diseases Volume: 84 ISSN: 1423-0356 ISO Abbreviation: Respiration Publication Date: 2012 |
Date Detail:
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Created Date: 2012-09-28 Completed Date: 2013-03-11 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0137356 Medline TA: Respiration Country: Switzerland |
Other Details:
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Languages: eng Pagination: 299-305 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arterial Pressure Cross-Sectional Studies Endothelin-1 / metabolism* Female Humans Hypertension, Pulmonary / etiology, metabolism* Idiopathic Pulmonary Fibrosis / complications, metabolism* Male Middle Aged Prospective Studies Pulmonary Artery / physiopathology* Vascular Endothelial Growth Factor A / metabolism* Vascular Resistance |
| Grant Support | |
ID/Acronym/Agency:
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K23 HL086714/HL/NHLBI NIH HHS; K23HL086714/HL/NHLBI NIH HHS; KL2 RR024156/RR/NCRR NIH HHS; L30 HL086095/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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