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Plasma Desmoplakin I Biomarker Of Vascular Recurrence After Ischemic Stroke.
MedLine Citation:
PMID:  22304020     Owner:  NLM     Status:  Publisher    
Background:  Stroke patients have a high risk of vascular recurrence. Biomarkers related to vascular recurrence, however, remain to be identified. Our aim was to identify, through proteomic analysis, plasma biomarkers associated with vascular recurrence within one year after the first ischemic stroke. Methods:  This is a substudy (n=134) of a large prospective multicenter study of post-stroke patients with an ischemic stroke. Plasma samples were obtained at inclusion. Results:  Among the identified proteins, only plasma levels of desmoplakin I were associated with protection against a new vascular event (Odds ratio: 0.64; 95% CI: 0.46-0.89; p=0.009) after adjustment for hypercholesterolemia, statins and previous atherothrombotic stroke subtype. A greater number of patients without vascular recurrence had been treated with statins within three months of the recent ischemic stroke. Only patients who had been taking statins for 3 months after the ischemic stroke and did not suffer vascular recurrence over a follow-up year, have higher levels of desmoplakin I at the time of inclusion (Odds ratio 0.49: 95% CI: 0.28-0.86; p=0.013). Conclusions:  Increased desmoplakin I levels, determined within 1 to 3 months of the first ischemic stroke, could be a biomarker for statin responsiveness against a new vascular event in post-ischemic stroke patients taking statins early (1 to 3 months) after the ischemic stroke. © 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry.
Antonio J López-Farré; José J Zamorano-León; Antonio Segura; Petra J Mateos-Cáceres; Javier Modrego; Pablo Rodríguez-Sierra; Laura Calatrava; Juan Tamargo; Carlos Macaya
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-4
Journal Detail:
Title:  Journal of neurochemistry     Volume:  -     ISSN:  1471-4159     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Journal of Neurochemistry © 2012 International Society for Neurochemistry.
Cardiovascular Research Unit. Cardiology Department Cardiovascular Institute. Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Health Sciences Institute. Talavera de la Reina, Toledo, Spain. Pharmacology Department, School of Medicine, Universidad Complutense de Madrid, Spain.
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