Document Detail

Plasma cystatin C concentration reflects the severity of coronary artery disease in patients without chronic kidney disease.
MedLine Citation:
PMID:  20921817     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study examines whether the serum concentration of cystatin C (Cys C) correlates with the severity of coronary artery disease (CAD) and whether it provides additional information on the risk for CAD in patients without chronic kidney disease (CKD) estimated by the creatinine-based glomerular filtration rate (GFR).
METHODS AND RESULTS: The relationship between serum Cys C and the severity of CAD in 526 patients was investigated. Based on GFR, patients were divided into those with and without CKD. The relationship of serum Cys C with the severity of CAD was examined. Serum Cys C was closely correlated with GFR in all cases and in CKD patients, but not in non-CKD patients. The average number of stenotic coronary arteries was significantly higher in the quartiles of higher concentration of Cys C as well as in those of GFR. In 348 patients (66%) the GFR was ≥60 ml · min(-1)·1.73 m(-2). Those patients with increased Cys C (>0.90 mg/L, 143 patients) had a significantly larger number of stenotic coronary arteries than those patients with normal Cys C.
CONCLUSIONS: Among patients considered to be at low risk based on the estimated GFR using serum creatinine, those with high concentrations of Cys C could have severe CAD. Besides CKD, Cys C might serve as a marker of CAD severity.
Arihiro Kiyosue; Yasunobu Hirata; Jiro Ando; Hideo Fujita; Toshihiro Morita; Masao Takahashi; Daisuke Nagata; Takahide Kohro; Yasushi Imai; Ryozo Nagai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-29
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  74     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2010-11-30     Revised Date:  2011-02-18    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2441-7     Citation Subset:  IM    
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
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MeSH Terms
Biological Markers / blood
Chi-Square Distribution
Chronic Disease
Coronary Angiography
Coronary Stenosis / blood,  diagnosis*,  radiography
Creatinine / blood
Cystatin C / blood*
Glomerular Filtration Rate
Immunoenzyme Techniques
Kidney Diseases / blood,  diagnosis*,  physiopathology
Least-Squares Analysis
Middle Aged
Odds Ratio
Predictive Value of Tests
Retrospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Reg. No./Substance:
0/Biological Markers; 0/CST3 protein, human; 0/Cystatin C; 60-27-5/Creatinine

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