| Plasma Cyclic 3',5'-Adenosine Monophosphate in Patients With Elevated Pulmonary Pressure Due to Left-to-Right Shunt. | |
| | |
MedLine Citation:
|
PMID: 21652166 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Increased pulmonary blood flow in patients with left-to-right shunt has been shown to be associated with alterations in prostacyclin-synthesis. There are limited data with respect to the plasma cAMP in patients with elevated pulmonary artery pressure due to left-to-right shunt. We hypothesized that plasma cAMP might be influenced by pulmonary blood flow or pressure in patients with left-to-right shunt. METHODS: Plasma cAMP from venous blood was measured in 122 healthy controls aged 8.3 (0.2 - 14.9) years (median [range]) and in 130 patients with left-to-right shunt aged 1.4 (0.1 - 19.1) years by radioimmunoassay. RESULTS: Plasma cAMP in controls and in patients was similar and decreased with age. Healthy infants (n = 42) showed higher plasma cAMP (46 [27-112] nmol/l) than children > 6 years of age (n = 40, 39 [19-73] nmol/l; P < 0.001). CONCLUSIONS: These values should be taken into consideration when reporting plasma values for cAMP in patients with congenital heart disease. The values for healthy children obtained in this study should allow a better interpretation of plasma cAMP levels in various disease conditions such as chronic renal failure, liver chirrhosis, hyperthyreosis, or children with intellectual disability. |
| | |
Authors:
|
Tsvetomir Loukanov; Hiroaki Takahashi; Pencho Tonchev; Jasmin Gross; Markus Bettendorf; Matthias Gorenflo |
Related Documents
:
|
700326 - Hepatic iron clearance from serum in treated hemochromatosis. 3771426 - Antibacterial interaction of cefuroxime and serum from uraemic patients. 17740936 - Dense astrophysical plasmas. 1308796 - A study of erythropoiesis and iron metabolism in the rabbit in vivo. ii. dependence of ... 10583266 - Increased serum levels of vascular endothelial growth factor predict risk of progressio... 178246 - Experimental induction of hypoparathyroidism with parathyroid hormone antibodies. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-6 |
Journal Detail:
|
Title: The Canadian journal of cardiology Volume: - ISSN: 1916-7075 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Cardiac Surgery, University Medical Centre, Heidelberg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel mutation in the RYR2 gene leading to catecholaminergic polymorphic ventricular tachycardia a...
Next Document: Influenza Myocarditis and Myositis: Case Presentation and Review of the Literature.