Document Detail


Plasma Copeptin in Preterm Infants: A Highly Sensitive Marker of Fetal and Neonatal Stress.
MedLine Citation:
PMID:  21450985     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Context: Copeptin is a stable by-product of arginine-vasopressin synthesis and reflects its secretion by the pituitary. Objective: The objective of the study was to investigate perinatal factors affecting copeptin concentrations in preterm infants at birth and at 3 d of life. Design and Setting: This was a prospective cross-sectional study at two Swiss university hospitals. Patients: One hundred sixty-seven preterm infants were enrolled, 59 infants born between 24 and 31 wk gestational age, 50 infants between 32 and 34 wk, and 58 between 35 and 36 wk. Main Outcome Measure: Plasma copeptin concentrations, determined by a CT-proAVP-luminescence-immunoassay, were measured. Results: Copeptin at birth was significantly higher in preterm infants born vaginally [median (range) 366 (1-2900) pmol/liter, n = 43] than those born by cesarean section [6.9 (2-1580), n = 124]. In infants born after cesarean without prior labor (n = 66), estimated fetal weight less than the fifth percentile, suspect fetal heart rate, compromised placental perfusion, and chorioamnionitis were each associated with significantly elevated cord copeptin. Copeptin at 3 d of life was not associated with cord blood copeptin but inversely related to gestational age (Rs = -0.6, P < 0.001) and birth weight (Rs -0.612, P < 0.001). Day 3 copeptin increased alongside the level of mechanical respiratory support. Conclusion: Copeptin is a highly sensitive marker of perinatal stress.
Authors:
Jörg Benzing; Sven Wellmann; Federica Achini; Julia Letzner; Tilo Burkhardt; Ernst Beinder; Nils G Morgenthaler; Ulrike Haagen; Hans Ulrich Bucher; Christoph Bührer; Olav Lapaire; Gabor Szinnai
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-30
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Neonatology (J.B., F.A.) and Department of Pediatric Endocrinology (G.S.), University Children's Hospital Basel, CH-4056 Basel, Switzerland; Divisions of Neonatology (S.W., J.L., H.U.B.) and Obstetrics (T.B.), University Hospital Zurich, CH-8091 Zurich, Switzerland; Departments of Obstetrics (E.B.) and Neonatology (C.B.), Charité University Medical Center, D-10117 Berlin, Germany; Research Department (N.G.M., U.H.), BRAHMS Biomarkers, part of Thermo Fisher Scientific Hennigsdorf, D-16761 Hennigsdorf/Berlin, Germany; and Division of Obstetrics and Gynecology (O.L.), University Hospital Basel, CH-4031 Basel, Switzerland.
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