Document Detail

Plasma Concentration and Cardiovascular Effects of Lidocaine during Continuous Epidural Administration in Dogs Anesthetized with Isoflurane.
MedLine Citation:
PMID:  21048393     Owner:  NLM     Status:  In-Data-Review    
The cardiovascular effects of continuous epidural administration (CEA) of lidocaine were investigated in anesthetized dogs. Loading epidural injections of 2, 4, or 6 mg/kg of lidocaine were followed by CEA with 1, 2, or 3 mg/kg/hr lidocaine, respectively, for 2 hr under 2.0% isoflurane anesthesia. Heart rate, direct blood pressure, cardiac index, and stroke volume decreased dose-dependently during CEA, whereas systemic vascular resistance did not significantly differ with dose, and no characteristic changes were observed in any groups. Plasma lidocaine concentration reached a steady state during CEA and increased in a dose-dependent manner. Circulatory suppression caused by lidocaine CEA was not attributable to peripheral vasodilation, but rather to the direct cardiac action of systemic lidocaine absorption from the peridural space.
Iwao Sakonju; Kenichi Maeda; Koichi Karasawa; Toshiyuki Tadokoro; Tomoko Kakuta; Katsuaki Takase
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Publication Detail:
Type:  Journal Article     Date:  2010-11-01
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  73     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  393-8     Citation Subset:  IM    
Department of Small Animal Surgery 1, School of Veterinary Medicine, Kitasato University.
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