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Plasma Concentration and Cardiovascular Effects of Lidocaine during Continuous Epidural Administration in Dogs Anesthetized with Isoflurane.
MedLine Citation:
PMID:  21048393     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The cardiovascular effects of continuous epidural administration (CEA) of lidocaine were investigated in anesthetized dogs. Loading epidural injections of 2, 4, or 6 mg/kg of lidocaine were followed by CEA with 1, 2, or 3 mg/kg/hr lidocaine, respectively, for 2 hr under 2.0% isoflurane anesthesia. Heart rate, direct blood pressure, cardiac index, and stroke volume decreased dose-dependently during CEA, whereas systemic vascular resistance did not significantly differ with dose, and no characteristic changes were observed in any groups. Plasma lidocaine concentration reached a steady state during CEA and increased in a dose-dependent manner. Circulatory suppression caused by lidocaine CEA was not attributable to peripheral vasodilation, but rather to the direct cardiac action of systemic lidocaine absorption from the peridural space.
Authors:
Iwao Sakonju; Kenichi Maeda; Koichi Karasawa; Toshiyuki Tadokoro; Tomoko Kakuta; Katsuaki Takase
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Publication Detail:
Type:  Journal Article     Date:  2010-11-01
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  73     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  393-8     Citation Subset:  IM    
Affiliation:
Department of Small Animal Surgery 1, School of Veterinary Medicine, Kitasato University.
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