| Plasma Ceruloplasmin Ferroxidase Activity Correlates with the Nigral Sonographic Area in Parkinson's Disease Patients: A Pilot Study. | |
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MedLine Citation:
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PMID: 21706376 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Increased area of the substantia nigra (SN) associated to iron deposition has been proposed as a specific marker for Parkinson's disease (PD). Echogenicity, assessed by transcranial sonography (TCS), has been used to measure such an iron deposition. On the other hand, ferroxidase activity is known to play a role in brain iron metabolism and thus could be involved in increased SN echogenicity of PD patients. The present study was conducted to search for a possible correlation between both markers: TCS of SN and plasma ferroxidase activity. Twenty-one PD patients and 13 healthy volunteers (HV) were included. Mean SN sonographic areas were 0.31 cm(2) for PD patients and 0.12 cm(2) for HV (P < 0.001), while plasma ferroxidase activity was reduced in PD patients (P < 0.001). Interestingly, plasma ferroxidase activity was inversely correlated with the SN size by TCS (R(2) = 0.31), suggesting a relationship between the two markers. |
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Authors:
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Rubén Martínez-Hernández; Sergio Montes; Jesus Higuera-Calleja; Petra Yescas; Marie-Catherine Boll; Araceli Diaz-Ruiz; Camilo Rios |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-26 |
Journal Detail:
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Title: Neurochemical research Volume: - ISSN: 1573-6903 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Neurology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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