Document Detail


Plasma C-terminal pro-endothelin-1 is associated with left ventricular mass index and aortic root diameter in African-American adults with hypertension.
MedLine Citation:
PMID:  20182452     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endothelin-1 (ET-1), a circulating vasoactive peptide with potent vasoconstricting and mitogenic properties, may contribute to target-organ damage in hypertension. We investigated whether plasma levels of C-terminal pro-endothelin-1 (CT-pro-ET-1) are associated with left ventricular (LV) mass and aortic root diameter in African-American adults with hypertension. Plasma CT-pro-ET-1 was measured by an immunoluminometric assay in 1041 African Americans (65±9 years, 72% women) with hypertension. LV mass and aortic root diameter were measured according to the American Society of Echocardiography guidelines, and LV mass was indexed by height to the power 2.7 (LVMi). Multivariable regression analyses were used to assess whether plasma CT-pro-ET-1 was associated with LVMi and aortic root diameter, independent of potential confounding variables. Plasma CT-pro-ET-1 was modestly correlated with LVMi (r=0.21, P<0.0001) and aortic root diameter (r=0.09, P=0.004). In separate multivariable regression models that adjusted for age, sex, body mass index, total and high-density lipoprotein cholesterol, smoking history, diabetes, history of myocardial infarction or stroke, and blood pressure-lowering medication and statin use, log CT-pro-ET-1 was significantly associated with greater LVMi (P=0.001) and larger aortic root diameter (P=0.006). CT-pro-ET-1 is independently associated with LVMi and aortic root diameter and may be a marker of target-organ damage in African-Americans adults with hypertension.
Authors:
M A Al-Omari; M Khaleghi; T H Mosley; N G Morgenthaler; J Struck; A Bergmann; I J Kullo
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-02-25
Journal Detail:
Title:  Journal of human hypertension     Volume:  25     ISSN:  1476-5527     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-13     Completed Date:  2011-05-03     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  106-13     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
African Americans
Aged
Aortic Valve / pathology,  physiopathology*,  ultrasonography
Biological Markers
Confounding Factors (Epidemiology)
Echocardiography, Doppler
Endothelin-1 / blood*
Female
Heart Ventricles / pathology,  physiopathology*,  ultrasonography
Humans
Hypertension* / blood,  complications,  epidemiology,  physiopathology
Hypertrophy, Left Ventricular / blood*,  etiology,  physiopathology,  ultrasonography
Luminescent Measurements / methods*
Male
Middle Aged
Peptide Fragments / blood*
Regression Analysis
Risk Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
HL-81331/HL/NHLBI NIH HHS; M01 RR000585-35/RR/NCRR NIH HHS; M01 RR00585/RR/NCRR NIH HHS; U01 HL081331/HL/NHLBI NIH HHS; U01 HL081331-03/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/C-terminal proendothelin-1; 0/Endothelin-1; 0/Peptide Fragments
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease.
Next Document:  Preferential benefits of nifedipine GITS in systolic hypertension and in combination with RAS blocka...