Document Detail

Plasma C-reactive protein is related to cognitive deterioration and dementia in patients with mild cognitive impairment.
MedLine Citation:
PMID:  19419739     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the relationship between plasma C-reactive protein (CRP) and the risk for cognitive deterioration and development of dementia in patients with mild cognitive impairment (MCI). METHODS: Elderly Chinese patients with suspected cognitive impairment were screened. A total of 168 patients who met the criteria for MCI were enrolled. Plasma CRP levels were measured at baseline. The global cognitive functions were assessed at baseline and during follow-up periodically with Mini-Mental State Examination (MMSE). All enrolled patients were followed and evaluated regularly for 2 years to determine if the patients developed dementia. RESULTS: Of the 168 patients with MCI diagnosed at baseline, 14 (8.3%) deceased, 13 (7.7%) lost to follow-up, and 58 (34.5%) developed dementia during follow-up. MMSE score of the enrolled patients declined significantly during follow-up (22.1 +/- 3.0 vs 18.6 +/- 5.5, P < 0.001). MMSE score was significantly lower for the patients with high CRP levels than that for those with low plasma CRP levels (-4.9 +/- 5.4 vs -3.2 +/- 4.2, P < 0.05). Patients with high plasma CRP level had an increased risk for dementia and vascular dementia as compared with patients with low level of plasma CRP (Log rank test, P < 0.05). CONCLUSION: High plasma CRP level was associated with accelerated cognitive decline and increased risk for dementia in patients with MCI.
Gelin Xu; Zhiming Zhou; Wusheng Zhu; Xiaobing Fan; Xinfeng Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-05
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  284     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-05     Completed Date:  2009-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305# East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China.
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MeSH Terms
Alcohol Drinking / epidemiology
C-Reactive Protein / analysis*
Cardiovascular Diseases / epidemiology
China / epidemiology
Cognition Disorders / blood*,  diagnosis,  epidemiology
Dementia / blood*,  diagnosis,  epidemiology
Diabetes Mellitus / epidemiology
Disease Progression
Follow-Up Studies
Hyperlipidemias / epidemiology
Middle Aged
Psychiatric Status Rating Scales
Smoking / epidemiology
Reg. No./Substance:
9007-41-4/C-Reactive Protein

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