| Plasma C-reactive protein is related to cognitive deterioration and dementia in patients with mild cognitive impairment. | |
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MedLine Citation:
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PMID: 19419739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the relationship between plasma C-reactive protein (CRP) and the risk for cognitive deterioration and development of dementia in patients with mild cognitive impairment (MCI). METHODS: Elderly Chinese patients with suspected cognitive impairment were screened. A total of 168 patients who met the criteria for MCI were enrolled. Plasma CRP levels were measured at baseline. The global cognitive functions were assessed at baseline and during follow-up periodically with Mini-Mental State Examination (MMSE). All enrolled patients were followed and evaluated regularly for 2 years to determine if the patients developed dementia. RESULTS: Of the 168 patients with MCI diagnosed at baseline, 14 (8.3%) deceased, 13 (7.7%) lost to follow-up, and 58 (34.5%) developed dementia during follow-up. MMSE score of the enrolled patients declined significantly during follow-up (22.1 +/- 3.0 vs 18.6 +/- 5.5, P < 0.001). MMSE score was significantly lower for the patients with high CRP levels than that for those with low plasma CRP levels (-4.9 +/- 5.4 vs -3.2 +/- 4.2, P < 0.05). Patients with high plasma CRP level had an increased risk for dementia and vascular dementia as compared with patients with low level of plasma CRP (Log rank test, P < 0.05). CONCLUSION: High plasma CRP level was associated with accelerated cognitive decline and increased risk for dementia in patients with MCI. |
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Authors:
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Gelin Xu; Zhiming Zhou; Wusheng Zhu; Xiaobing Fan; Xinfeng Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-05 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 284 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-05 Completed Date: 2009-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 77-80 Citation Subset: IM |
Affiliation:
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Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305# East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China. gelinxu@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alcohol Drinking / epidemiology C-Reactive Protein / analysis* Cardiovascular Diseases / epidemiology China / epidemiology Cognition Disorders / blood*, diagnosis, epidemiology Comorbidity Dementia / blood*, diagnosis, epidemiology Diabetes Mellitus / epidemiology Disease Progression Female Follow-Up Studies Humans Hyperlipidemias / epidemiology Incidence Male Middle Aged Psychiatric Status Rating Scales Risk Smoking / epidemiology |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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