Document Detail


Plasma C-reactive protein in early pregnancy and preterm delivery.
MedLine Citation:
PMID:  16236995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Systemic maternal infections have been associated with preterm delivery. The authors examined the association of C-reactive protein (CRP), a marker of inflammation, with preterm delivery. This nested case-control study was conducted within Project Viva in Massachusetts between 1999 and 2002. Subjects were 117 women who delivered preterm (< 37 weeks' gestation) and 117 controls (term deliveries) matched on age, race/ethnicity, and smoking status. High-sensitivity CRP assays were performed on early-pregnancy (5.3-19.3 weeks' gestation) plasma samples. Odds ratios and 95% confidence intervals were estimated by using conditional logistic regression adjusted for matching factors, gestational age at blood collection, and prepregnancy body mass index. Median concentration of CRP was 3.2 mg/liter in cases versus 2.4 mg/liter in controls. No significant association was found between quartiles of CRP and preterm delivery. However, CRP levels exceeding the threshold defined in the literature were associated with increased risk of preterm delivery (odds ratio = 2.55, 95% confidence interval: 1.05, 6.02 for CRP > or = 8 mg/liter). The association was stronger among cases who experienced spontaneous delivery (odds ratio = 4.64, 95% confidence interval: 0.94, 22.96) versus indicated delivery (odds ratio = 1.42, 95% confidence interval: 0.44, 4.61). These findings suggest that very high CRP levels in early pregnancy are associated with preterm delivery.
Authors:
Waranuch Pitiphat; Matthew W Gillman; Kaumudi J Joshipura; Paige L Williams; Chester W Douglass; Janet W Rich-Edwards
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-10-19
Journal Detail:
Title:  American journal of epidemiology     Volume:  162     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-24     Completed Date:  2006-01-05     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1108-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / epidemiology
Biological Markers / blood
Body Mass Index
C-Reactive Protein / metabolism*
Case-Control Studies
Cohort Studies
Female
Gestational Age
Humans
Massachusetts / epidemiology
Multivariate Analysis
Odds Ratio
Pregnancy / blood*
Premature Birth / blood*,  epidemiology*
Prospective Studies
Recurrence
Grant Support
ID/Acronym/Agency:
DE14004/DE/NIDCR NIH HHS; HD34568/HD/NICHD NIH HHS; HL68041/HL/NHLBI NIH HHS; K24 HL068041/HL/NHLBI NIH HHS; K24 HL068041-03/HL/NHLBI NIH HHS; R01 HD034568/HD/NICHD NIH HHS; R01 HD034568-03/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein
Comments/Corrections

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