Document Detail


Plasma C-reactive protein and 5-lipoxygenase-activating protein gene promoter poly-A polymorphism in patients with coronary artery disease.
MedLine Citation:
PMID:  17627106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The purpose of this study was to explore the possible associations of the 5-lipoxygenase-activating protein (FLAP) poly-A genotype, plasma high-sensitivity C-reactive protein (hsCRP) and the extent score of coronary artery disease (CAD). METHODS: The 17A/21A genotypes and plasma hsCRP levels were determined in 555 Chinese patients, 424 with and 131 without CAD. The luciferase reporter assay was performed to explore the functional significance of promoter poly-A polymorphism. RESULTS: CAD patients showed significantly higher plasma hsCRP (p = 0.007) than non-CAD subjects, but no differences in the 17A allele carriers and frequency. The extent score of CAD was significantly correlated with plasma hsCRP (p = 0.03). Furthermore, the 17A allele carriers showed significantly higher hsCRP than the 21A homozygotes (p = 0.02). Multiple linear regression analysis documented an impact of the poly-A genotype on plasma hsCRP (p = 0.03). In vitro, the 17A construct was found to have greater promoter activity than the 21A construct (p = 0.02). CONCLUSIONS: The present study demonstrated a significant correlation of FLAP gene promoter 17A allele carriers with higher plasma hsCRP levels in patients with CAD. This association might be related to the increased transcriptional activity of the FLAP gene and the resulting pro-inflammatory effect on the 5-lipoxygenase pathway.
Authors:
Jing-Ren Jeng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-10
Journal Detail:
Title:  Cardiology     Volume:  109     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2008  
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-01-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  25-32     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel
Affiliation:
Division of Cardiology, Department of Internal Medicine, Buddhist Tzu-Chi General Hospital, Tzu-Chi University, Hualien, Taiwan, ROC. jrj4511@yahoo.com.tw
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Asian Continental Ancestry Group
C-Reactive Protein / metabolism*
Carrier Proteins / genetics*
Case-Control Studies
Cell Line
Coronary Angiography
Coronary Artery Disease / blood*,  genetics*
Female
Genotype
Humans
Male
Membrane Proteins / genetics*
Middle Aged
Myocardial Infarction / blood,  genetics
Poly A
Polymorphism, Genetic
Promoter Regions, Genetic
Regression Analysis
Chemical
Reg. No./Substance:
0/5-lipoxygenase-activating protein; 0/Carrier Proteins; 0/Membrane Proteins; 24937-83-5/Poly A; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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