Document Detail

Plasma C-peptide levels identify insulin-treated diabetic patients suitable for oral hypoglycaemic therapy.
MedLine Citation:
PMID:  6242818     Owner:  NLM     Status:  MEDLINE    
Plasma C-peptide levels were measured fasting and 2 h after an oral glucose load in 37 insulin-treated diabetic patients to assess their clinical value in identifying any noninsulin-dependent diabetic patients. All subjects were changed from insulin to oral hypoglycaemic therapy and followed for 3 months. Twenty patients (group A) completed the trial without requiring insulin and 17 (group B) required restabilization on insulin due to deteriorating metabolic control. Fasting and 2 h C-peptide levels were significantly higher in group A (0.11 +/- 0.09 and 0.17 +/- 0.12 nmol/l; mean +/- S.D.) compared with group B (0.02 +/- 0.03 and 0.02 +/- 0.03 nmol/l) (p less than 0.002 and p less than 0.002). The fasting C-peptide levels at 3 months (0.28 +/- 0.14 nmol/l) were also significantly higher than the fasting levels at the beginning of the study (p less than 0.002). Fasting and 2-h glucose levels were lower in group A (11.0 +/- 3.7 and 17.6 +/- 5.2 mmol/l) than in group B (14.4 +/- 6.2 and 23.1 +/- 5.9 mmol/l; p less than 0.05 and 0.02, respectively). The differences in glycosylated haemoglobin and fasting glucose levels at the start of the study and after 3 months of oral therapy were not statistically significant. Although C-peptide values overlapped in groups A and B, they were of greater value in identifying patients suitable for oral therapy than any single clinical criterion, and thus may help in identifying insulin-treated diabetic patients who may be treated with oral therapy without deterioration in metabolic control.
P J Grant; E Barlow; D W Miles
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  1     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1988-01-22     Completed Date:  1988-01-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  284-6     Citation Subset:  IM    
Airedale General Hospital, Steeton, W. Yorkshire, U.K.
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MeSH Terms
Aged, 80 and over
Blood Glucose / metabolism
C-Peptide / blood*
Diabetes Mellitus, Type 2 / blood*,  drug therapy
Hypoglycemic Agents / therapeutic use*
Insulin / therapeutic use*
Middle Aged
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 0/Hypoglycemic Agents; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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