| Plasma B-type natriuretic peptide concentration in beta-thalassaemia patients. | |
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MedLine Citation:
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PMID: 17300987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Plasma B-type natriuretic peptide (BNP) concentration has significant diagnostic accuracy and prognostic value in various forms of heart disease. Whether BNP is also useful in the evaluation and management of thalassaemia heart disease remains to be determined. METHODS AND RESULTS: Eighty three thalassaemia major patients; 8 with acutely decompensated heart failure (New York Heart Association [NYHA] class III or IV, group A), 25 with NYHA class II symptoms and impaired systolic left ventricular function (ejection fraction<55% or fractional shortening<30%, group B) and 50 with normal systolic function (group C), as well as 50 healthy controls, were studied. Assessment included history, physical examination, Doppler echocardiography and plasma BNP determination. Mean BNP levels were 431+/-219 pg/mL (range, 283-890 pg/mL) in group A, 158+/-31 pg/mL in group B, 176+/-54 pg/mL in group C and 43+/-24 pg/mL in controls. BNP levels were significantly higher in group A (p<0.001), but did not differ between groups B and C. Moreover, BNP was not correlated with left ventricular end-diastolic diameter, left ventricular mass, right ventricular diameter index, Doppler diastolic indexes (except in group C), the mean 2-year serum ferritin concentration or the peak serum ferritin concentration in any of the three patient groups. CONCLUSION: A potential deficiency of BNP-related neurohormonal mechanisms may impair its clinical usefulness in thalassaemia major. |
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Authors:
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Athanasios Aessopos; Dimitrios Farmakis; Aikaterini Polonifi; Maria Tsironi; Christina Fragodimitri; Antonia Hatziliami; Markisia Karagiorga; Evanthia Diamanti-Kandarakis |
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Publication Detail:
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Type: Journal Article Date: 2007-02-14 |
Journal Detail:
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Title: European journal of heart failure Volume: 9 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-17 Completed Date: 2007-09-20 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 537-41 Citation Subset: IM |
Affiliation:
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Cardiac Outpatient Clinic for Hemoglobinopathies, First Department of Internal Medicine, University of Athens Medical School, Laiko General Hospital, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Analysis of Variance Biological Markers / blood Case-Control Studies Echocardiography, Doppler Female Ferritins / blood Greece Heart Failure / blood, etiology, physiopathology, ultrasonography Humans Male Natriuretic Peptide, Brain / blood* Research Design Stroke Volume Ventricular Dysfunction, Left / blood, etiology, physiopathology, ultrasonography beta-Thalassemia / blood*, complications |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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