| Plasma apelin and ADMA Levels in patients with essential hypertension. | |
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MedLine Citation:
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PMID: 20504125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both apelin and asymetric dymethyl arginine (ADMA) regulate blood pressures. Low apelin and high ADMA levels have been reported in several cardiometabolic disorders. However, there is no data about ADMA and apelin levels in essential hypertension and any relationship between them. We investigated a group of newly diagnosed and untreated 30 young hypertensive men and 30 healthy controls. Apelin levels were significantly lower and the ADMA levels were significantly higher in the patients (p = 0.04 for both). Both ADMA and apelin were related to the systolic blood pressures (SBP) (beta = -0.393, p = 0.003; beta = 0.285, p = 0.03, respectively). Future studies are necessary in order to clearly define the role of ADMA and apelin in the pathogenesis of essential hypertension. |
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Authors:
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Alper Sonmez; Gurkan Celebi; Gokhan Erdem; Serkan Tapan; Halil Genc; Ilker Tasci; Cemal Nuri Ercin; Teoman Dogru; Selim Kilic; Gokhan Uckaya; Mahmut Ilker Yilmaz; Mehmet Kemal Erbil; Mustafa Kutlu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 32 ISSN: 1525-6006 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 179-83 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Gulhane School of Medicine, 06018 Etlik Ankara, Turkey. alpersonmez@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arginine / analogs & derivatives*, blood Biological Markers / blood Blood Pressure / physiology Body Mass Index Case-Control Studies Endothelium, Vascular / physiopathology Enzyme Inhibitors Enzyme-Linked Immunosorbent Assay Humans Hypertension / blood*, diagnosis, physiopathology Intercellular Signaling Peptides and Proteins / blood*, metabolism Male Statistics, Nonparametric Young Adult |
| Chemical | |
Reg. No./Substance:
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0/APLN protein, human; 0/Biological Markers; 0/Enzyme Inhibitors; 0/Intercellular Signaling Peptides and Proteins; 30315-93-6/N,N-dimethylarginine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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