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Plasma Amino Acid Levels Discriminate Between Control Subjects and Mildly Depressed Elderly Women.
MedLine Citation:
PMID:  22871334     Owner:  NLM     Status:  Publisher    
BACKGROUND AND AIMS: Depression is the most common of all psychiatric disorders and the role of amino acid transmitters in this pathology has been recently studied. We undertook this study to investigate if the plasma levels of L-arginine, L-citrulline, L-glutamic acid, L-glutamine, L-asparagine and other amino acids, the L-citrulline/L-arginine and the L-tyrosine/L-phenylalanine ratios, and the nitrite levels are modified in mildly depressed women and if such changes are related to olfactory dysfunction. METHODS: Plasma samples were obtained from elderly female subjects (n = 21) with mild depression and (n = 48) controls. Amino acids were analyzed with high-performance liquid chromatography, plasma nitrite levels were measured using the Griess method, and olfactory performance was assessed by the combined testing of odor identification, odor discrimination, odor recognition, and the olfactory threshold. RESULTS: Compared to controls, depressed patients had a significantly higher concentration of L-arginine and a significantly lower L-citrulline/L-arginine ratio when the effect of other variables is not taken into account. A logistic regression model allowed us to identify two risk factors for mild depression, L-arginine and L-glutamic acid, and two protective factors, L-asparagine and the L-tyrosine/L-phenylalanine ratio. Additionally, a significant increase in nitrite levels in depressed women was found. No significant differences were found between the percentage of depressed and control women that identified the odors. CONCLUSIONS: We identified that the amino acids L-arginine and L-glutamic acid are risk factors for mild depression, whereas L-asparagine and the L-tyrosine/L-phenylalanine ratio are protective factors.
Adriana Mayoral-Mariles; Carmen Cruz-Revilla; Xochitl Vega-Manriquez; Rebeca Aguirre-Hernández; Patricia Severiano-Pérez; Eric Aburto-Arciniega; Araceli Jiménez-Mendoza; Rosalinda Guevara-Guzmán
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-4
Journal Detail:
Title:  Archives of medical research     Volume:  -     ISSN:  1873-5487     ISO Abbreviation:  Arch. Med. Res.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 IMSS. Published by Elsevier Inc. All rights reserved.
Departamento de Fisiología, Universidad Nacional Autónoma de México, México, D.F., México.
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