Document Detail


Plasma 5'-nucleotidase activities and uric acid levels in women with pre-eclampsia.
MedLine Citation:
PMID:  12571440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study investigated plasma activity of 5'-nucleotidase, a key enzyme in the production of adenosine, in pre-eclampsia, and evaluated the relationship between changes in 5'-nucleotidase activity, and levels of uric acid, endproduct of the purine metabolism, and the severity of pre-eclampsia. We measured plasma 5'-nucleotidase activities and uric acid levels in women with 18 normal pregnancies, mild and severe pre-eclampsia. In mild and severe pre-eclampsia, plasma 5'-nucleotidase activities and uric acid levels were significantly increased compared with those in normal pregnancy (p < 0.05). Plasma 5'-nucleotidase activity increased according to increases in uric acid levels and the severity of pre-eclampsia. These results suggest that increased plasma 5'-nucleotidase activity may, at least in part, be related to changes in purine metabolism in pre-eclampsia.
Authors:
Yoshio Yoneyama; Shunji Suzuki; Rintaro Sawa; Yasuo Otsubo; Atsushi Miura; Yoshimitsu Kuwabara; Hiroshi Ishino; Yasuko Kiyokawa; Daisuke Doi; Koichi Yoneyama; Hajime Kobayashi; Tsutomu Araki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  54     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2002  
Date Detail:
Created Date:  2003-02-06     Completed Date:  2003-05-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  168-71     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Affiliation:
Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan. yoshi-1@nms.ac.jp
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MeSH Terms
Descriptor/Qualifier:
5'-Nucleotidase / blood*
Adult
Case-Control Studies
Female
Humans
Pre-Eclampsia / blood*,  pathology
Pregnancy
Severity of Illness Index
Uric Acid / blood*
Chemical
Reg. No./Substance:
69-93-2/Uric Acid; EC 3.1.3.5/5'-Nucleotidase

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