| Plasma 3,4-dihydroxyphenylethyleneglycol and 3-methoxy-4-hydroxyphenylethyleneglycol as indicators of central noradrenergic activity. A comparative study on control subjects and depressed patients. | |
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MedLine Citation:
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PMID: 3075724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Animal studies have suggested interspecies differences in brain norepinephrine (NE) metabolism, especially with regard to the relative proportions of 3,4-dihydroxyphenylethyleneglycol (DOPEG) compared to 3-methoxy-4-hydroxyphenylethyleneglycol (MOPEG). In order to question the value of both glycol metabolites as peripheral indices of central noradrenergic activity, a comparative study of plasma DOPEG and MOPEG (measured by HPLC) related to depression, sex, age and diagnostic categories (DSM-III) was carried out on depressed and control subjects. In addition, two groups of 8 patients were randomly submitted to a desipramine 150 mg/day, or a metapramine 450 mg/day antidepressant treatment influencing the formation of DOPEG and MOPEG in a different way. The study did not demonstrate any difference between DOPEG and MOPEG for most of the experimental factors. We found also a significant positive correlation between plasma levels of DOPEG and MOPEG. Our results support the idea that each of these two biological indices can be used in the assessment of central noradrenergic activity. |
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Authors:
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J M Azorin; F Karege; M Valli; D Pringuey; P Joanny; R Tissot |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Neuropsychobiology Volume: 20 ISSN: 0302-282X ISO Abbreviation: Neuropsychobiology Publication Date: 1988 |
Date Detail:
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Created Date: 1989-08-25 Completed Date: 1989-08-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7512895 Medline TA: Neuropsychobiology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 67-73 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Timone Hospital, Aix-Marseille University, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antidepressive Agents, Tricyclic / therapeutic use Brain / metabolism* Clinical Trials as Topic Depressive Disorder / blood*, drug therapy Desipramine / therapeutic use Dibenzazepines / therapeutic use Female Glycols / blood* Humans Male Methoxyhydroxyphenylglycol / analogs & derivatives, blood* Middle Aged Norepinephrine / blood* Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Tricyclic; 0/Dibenzazepines; 0/Glycols; 21730-16-5/metapramine; 3343-19-9/dihydroxyphenylethylene glycol; 50-47-5/Desipramine; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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