Document Detail

Plasma 3-nitrotyrosine is elevated in premature infants who develop bronchopulmonary dysplasia.
MedLine Citation:
PMID:  9565417     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Premature infants are susceptible to bronchopulmonary dysplasia (BPD), a chronic lung disease of infancy that appears to be caused in part by oxidative stress from hyperoxia. To investigate the possible role of nitric oxide-derived oxidants such as peroxynitrite in the etiology of BPD, we measured levels of plasma 3-nitrotyrosine, which is produced by the reaction of peroxynitrite with proteins. PATIENTS AND METHODS: Ten premature infants who developed BPD, defined as requiring supplemental oxygen beyond 36 weeks' postmenstrual age, were identified retrospectively from a group of subjects enrolled in a clinical trial of antenatal therapy. Serial plasma samples had been collected on these infants during the first month of life as part of the trial. Sixteen comparison premature infants were identified from the same population: 5 had no lung disease, 6 had respiratory distress syndrome that resolved, and 5 had residual lung disease at 28 days of life that resolved by 36 weeks' postmenstrual age. Plasma 3-nitrotyrosine levels were measured using a solid phase immunoradiochemical method. RESULTS: All 3-nitrotyrosine values in infants without BPD were <0.25 ng/mg protein, and levels did not change with postnatal age. Plasma 3-nitrotyrosine concentrations were significantly higher in infants with BPD, increasing approximately fourfold during the first month of life. For the 20 infants who had blood samples available at 28 days of life, plasma 3-nitrotyrosine levels correlated with the fraction of inspired oxygen that the infant was receiving (r = 0.7). CONCLUSION: Plasma 3-nitrotyrosine content is increased during the first month of life in infants who develop BPD. This suggests that peroxynitrite-mediated oxidant stress may contribute to the development of this disease in premature infants and that 3-nitrotyrosine may be useful as an early plasma indicator of infants at risk for developing BPD.
B A Banks; H Ischiropoulos; M McClelland; P L Ballard; R A Ballard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  101     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-05-20     Completed Date:  1998-05-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  870-4     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Pennsylvania School of Medicine, Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia PA 19104, USA.
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MeSH Terms
Bronchopulmonary Dysplasia / blood*,  etiology
Infant, Newborn
Infant, Premature / blood*
Nitrates / metabolism
Oxidants / metabolism
Oxidative Stress
Pilot Projects
Retrospective Studies
Tyrosine / analogs & derivatives*,  blood
Grant Support
Reg. No./Substance:
0/Nitrates; 0/Oxidants; 26404-66-0/peroxynitric acid; 3604-79-3/3-nitrotyrosine; 55520-40-6/Tyrosine
Comment In:
Pediatrics. 1999 Feb;103(2):533-4   [PMID:  10026067 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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