Document Detail


Plasma 25-hydroxyvitamin D during pregnancy and small-for-gestational age in black and white infants.
MedLine Citation:
PMID:  22658824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: In a prospective prenatal cohort study, we examined associations of second trimester and cord plasma 25-hydroxyvitamin D (25[OH]D) with small-for-gestational age (SGA) and the extent to which vitamin D might explain black/white differences in SGA.
METHODS: We studied 1067 white and 236 black mother-infant pairs recruited from eight obstetrical offices early in pregnancy in Massachusetts. We analyzed 25(OH)D levels using an immunoassay and performed multivariable logistic models to estimate the odds of SGA by category of 25(OH)D level.
RESULTS: Mean (SD) second trimester 25(OH)D level was 60 nmol/L (SD, 21) and was lower for black (46 nmol/L [SD, 22]) than white (62 nmol/L [SD, 20]) women. Fifty-nine infants were SGA (4.5%), and more black than white infants were SGA (8.5% vs. 3.7%). The odds of SGA were higher with maternal 25(OH)D levels less than 25 versus 25 nmol/L or greater (adjusted odds ratio, 3.17; 95% confidence interval, 1.16-8.63). The increased odds of SGA among black versus white participants decreased from an odds ratio of 2.04(1.04, 4.04) to 1.68(0.82, 3.46) after adjusting for 25(OH)D.
CONCLUSIONS: Second trimester 25(OH)D levels less than 25 nmol/L were associated with higher odds of SGA. Our data raise the possibility that vitamin D status may contribute to racial disparities in SGA.
Authors:
Heather H Burris; Sheryl L Rifas-Shiman; Carlos A Camargo; Augusto A Litonjua; Susanna Y Huh; Janet W Rich-Edwards; Matthew W Gillman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-01
Journal Detail:
Title:  Annals of epidemiology     Volume:  22     ISSN:  1873-2585     ISO Abbreviation:  Ann Epidemiol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-13     Completed Date:  2012-10-26     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Neonatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. heburris@bidmc.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
African Americans / statistics & numerical data*
Cohort Studies
European Continental Ancestry Group / statistics & numerical data*
Female
Fetal Blood / chemistry
Fetal Development / physiology
Health Status Disparities*
Humans
Infant, Newborn
Infant, Small for Gestational Age / blood*
Logistic Models
Massachusetts
Pregnancy
Pregnancy Trimester, Second / blood*
Prospective Studies
Vitamin D / analogs & derivatives*,  blood
Grant Support
ID/Acronym/Agency:
HD 034568/HD/NICHD NIH HHS; HL 064925/HL/NHLBI NIH HHS; HL 068041/HL/NHLBI NIH HHS; K24 HL068041/HL/NHLBI NIH HHS; R01 HD034568/HD/NICHD NIH HHS; R01 HL064925/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D
Comments/Corrections

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