| Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans. | |
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MedLine Citation:
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PMID: 20351344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vitamin D regulates the renin-angiotensin system (RAS) in experimental animals, but corresponding human data are limited. We examined the relation between plasma 25-hydroxyvitamin D and elements of the RAS in 184 normotensive individuals in high sodium balance; these included circulating levels of plasma renin activity and angiotensin II (Ang II) and the renal plasma flow response to infused Ang II, which is an indirect measure of the intrinsic RAS activity in the kidney. Compared with individuals with sufficient 25-hydroxyvitamin D levels (> or = 30.0 ng/mL), those with insufficiency (15.0 to 29.9 ng/mL) and deficiency (<15.0 ng/mL) had higher circulating Ang II levels (P for trend=0.03). Moreover, those with vitamin D deficiency had significantly blunted renal plasma flow responses to infused Ang II (mean decrease of 115 mL/min per 1.73 m(2) in renal plasma flow versus 145 mL/min per 1.73 m(2) among those with sufficient vitamin D levels; P for trend=0.009). Although plasma renin activity was higher among individuals with insufficient levels of vitamin D, the result was not statistically significant. These data suggest that low plasma 25-hydroxyvitamin D levels may result in upregulation of the RAS in otherwise healthy humans. |
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Authors:
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John P Forman; Jonathan S Williams; Naomi D L Fisher |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-03-29 |
Journal Detail:
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Title: Hypertension Volume: 55 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-15 Completed Date: 2010-05-28 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 1283-8 Citation Subset: IM |
Affiliation:
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Renal Division and Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. jforman@partners.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Continental Ancestry Group Angiotensin II / blood, drug effects, pharmacology* European Continental Ancestry Group Female Homeostasis Humans Infusions, Intravenous Male Middle Aged Patient Selection Reference Values Renal Circulation / drug effects Renin-Angiotensin System / drug effects, physiology* Sodium / blood Sodium, Dietary / pharmacology* Vitamin D / analogs & derivatives*, blood, pharmacology p-Aminohippuric Acid / administration & dosage, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL079929/HL/NHLBI NIH HHS; HL084236/HL/NHLBI NIH HHS; K08 HL079929-05/HL/NHLBI NIH HHS; K23 HL084236-04/HL/NHLBI NIH HHS; K23 HL084236-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sodium, Dietary; 11128-99-7/Angiotensin II; 1406-16-2/Vitamin D; 61-78-9/p-Aminohippuric Acid; 64719-49-9/25-hydroxyvitamin D; 7440-23-5/Sodium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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