| Plasma 19-hydroxy-androstenedione (19-OH-A) in essential hypertension. | |
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MedLine Citation:
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PMID: 1330385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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19-hydroxy-androstenedione (19-OH-A), a C19 steroid, is an amplifier of the sodium retaining action of aldosterone under the control of ACTH and renin-angiotensin system. These findings suggest that 19-OH-A may be involved in the regulation of hydroelectrolyte balance and blood pressure. Aim of the present study was to examine the behaviour of 19-OH-A in normal volunteers (N) and in patients with Essential Hypertension (EH) in basal conditions and after dynamic tests such as postural changes, physical exercise and ACTH administration. The significant increase in 19-OH-A after ACTH confirms its adrenal origin. During bicycle exercise the significant increase in plasma catecholamines, renin-activity, aldosterone, blood pressure and heart rate at maximum effort was not associated with a parallel increase in 19-OH-A. No significant differences were found in plasma 19-OH-A levels between N and EH patients both in basal conditions and after dynamic tests. Therefore, our findings seem to exclude an important role of 19-OH-A in the pathogenesis of EH. |
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Authors:
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C Tosti-Croce; R Rinaldi; M Massaria; A Lomurno; T Felicioli; F Sciarra |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental hypertension. Part A, Theory and practice Volume: 14 ISSN: 0730-0077 ISO Abbreviation: Clin Exp Hypertens A Publication Date: 1992 |
Date Detail:
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Created Date: 1992-12-08 Completed Date: 1992-12-08 Revised Date: 2008-02-12 |
Medline Journal Info:
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Nlm Unique ID: 8207790 Medline TA: Clin Exp Hypertens A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1083-94 Citation Subset: IM |
Affiliation:
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Istituto di Clinica Medica V, Università La Sapienza, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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pharmacology Adult Aldosterone / blood Androstenedione / analogs & derivatives*, blood Catecholamines / blood Exercise Test Humans Hypertension / blood* Middle Aged Renin / blood Supine Position |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 510-64-5/19-hydroxy-4-androstene-3,17-dione; 52-39-1/Aldosterone; 63-05-8/Androstenedione; 9002-60-2/Adrenocorticotropic Hormone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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