Document Detail

Plasma 17-alpha-OH-progesterone in male workers exposed to traffic pollutants.
MedLine Citation:
PMID:  17284890     Owner:  NLM     Status:  MEDLINE    
The aim of the study is to evaluate if the occupational exposure to urban pollutants could cause alterations on 17-alfa-hydroxy-progesterone plasma levels and related diseases in male traffic policemen. 17-alpha-OH-P is synthesized in Leydig cells and in adrenals; it influences spermiogenesis, acrosoma reaction, testosterone biosynthesis, blocking of gonadotropin secretion; it regulates learning, memory and sleep. After excluding principal confounding factors, i.e., rotating or night shifts, exposure to solvents, paints and pesticides during time-off and smoking, traffic policemen were matched with controls by age, working life and drinking habit. Finally, 112 traffic policemen and 112 controls were included in the study. In traffic policemen 17-alpha-OH-P mean values were significantly higher vs. controls. The distribution of 17-alpha-OH-P values in both groups was significant. An increased frequency of fertility disorders referred to the questionnaire items were found in traffic policemen vs. controls, but the difference was not significant. The occupational exposure to low doses of chemical urban stressor, interacting with and adding to the psychosocial ones, could alter plasma 17-alpha-OH-P concentrations in traffic policemen vs. controls. 17-alpha-OH-P could be used as an early biological marker, even before the onset of the reproductive and mental health diseases.
Gianfranco Tomei; Manuela Ciarrocca; Andrea Bernardini; Assuntina Capozzella; Maria Valeria Rosati; Vincenza Anzelmo; Tiziana Caciari; Claudia Cardella; Carlo Monti; Francesco Tomei
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Industrial health     Volume:  45     ISSN:  0019-8366     ISO Abbreviation:  Ind Health     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985065R     Medline TA:  Ind Health     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  170-6     Citation Subset:  IM    
University of Rome La Sapienza, Department of Occupational Medicine, Viale Regina Elena 336, 00161 Rome, Italy.
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MeSH Terms
17-alpha-Hydroxyprogesterone / blood*
Air Pollutants, Occupational*
Middle Aged
Occupational Exposure*
Reproductive Medicine
Vehicle Emissions*
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Vehicle Emissions; 68-96-2/17-alpha-Hydroxyprogesterone

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