Document Detail

Plaque instability in peripheral vessels.
MedLine Citation:
PMID:  12077716     Owner:  NLM     Status:  MEDLINE    
Vulnerable atherosclerotic plaques, those that are prone to rupture, are soft and lipid rich. Other factors that contribute to destabilizing these plaques are inflammation and vasoconstriction. Although less information is available regarding noncoronary vulnerable plaques than the more frequently studied coronary plaques, it appears that the amount of soft lipid "gruel" as well as in situ inflammation plays a crucial role in destabilizing peripheral vascular atherosclerotic plaque, eventually causing its rupture. As in the coronary circulation, it is likely that the majority of acute plaque rupture events are clinically silent. Nevertheless, preventing plaque rupture in the noncoronary circulation is of the utmost importance because this is the presumed mechanism of progression of peripheral vascular atherosclerotic lesions.
Jose A Silva; Christopher J White
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  44     ISSN:  0033-0620     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-06-21     Completed Date:  2002-07-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-36     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2002, Elsevier Science (USA). All rights reserved.
Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA.
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MeSH Terms
Arteriosclerosis / physiopathology*
Blood Circulation / physiology
Factor VII / physiology*
Peripheral Vascular Diseases / physiopathology*
Rupture, Spontaneous / physiopathology
Reg. No./Substance:
9001-25-6/Factor VII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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