Document Detail

Plaque characteristics of the coronary segment proximal to the culprit lesion in stable and unstable patients.
MedLine Citation:
PMID:  19455670     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Identifying vulnerable plaque is important for preventing an acute coronary event. The present study examined the relationship between the clinical presentation of coronary artery disease and the plaque characteristics of nonculprit segment assessed by virtual histology intravascular ultrasound (VH-IVUS). METHOD: We performed VH-IVUS analysis on nonculprit segments with < 50% diameter stenosis in 91 patients (48 acute coronary syndrome [ACS] patients, 43 stable angina [SA] patients). RESULTS: ACS patients showed significantly higher ratio of dense calcium (7.9% +/- 1.0% versus 5.0% +/- 0.9%, p = 0.03) and necrotic core plaque (13.7% +/- 1.1% versus 8.6% +/- 1.1%, p = 0.001) compared with SA patients. VH-IVUS-derived thin-cap fibroatheroma (VH-TCFA) was more frequently observed in ACS patients compared with SA patients (64.6% versus 35.7%, p = 0.006). Among ACS patients, plasma high sensitivity C-reactive protein (hs-CRP) levels were significantly higher in patients with VH-TCFA than in patients without VH-TCFA (7.9 +/- 2.6 mg/l versus 1.6 +/- 0.3 mg/l, p = 0.004). CONCLUSION: ACS patients presented higher prevalence of VH-TCFA in nonculprit segment. Presence of VH-TCFA was associated with an increased level of plasma hs-CRP in ACS patients.
Tomohiro Nakamura; Norifumi Kubo; Hiroshi Funayama; Yoshitaka Sugawara; Junya Ako; Shin-ichi Momomura
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  32     ISSN:  1932-8737     ISO Abbreviation:  -     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-24     Completed Date:  2009-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E9-12     Citation Subset:  IM    
Cardiovascular Division, Jichi Medical University, Saitama Medical Center, Saitama, Japan.
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MeSH Terms
Acute Coronary Syndrome / etiology,  pathology,  ultrasonography*
Angina Pectoris / etiology,  pathology,  ultrasonography*
Biological Markers / blood
C-Reactive Protein / metabolism
Calcinosis / ultrasonography
Coronary Stenosis / complications,  pathology,  ultrasonography*
Coronary Vessels / pathology,  ultrasonography*
Middle Aged
Severity of Illness Index
Ultrasonography, Interventional*
User-Computer Interface
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

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