| Planum temporale analysis via a new volumetric method in autoptic brains of demented and psychotic patients. | |
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MedLine Citation:
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PMID: 19199877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Investigations of alterations in brain asymmetry often focus on the planum temporale of patients with schizophrenia. Data also suggest changes in laterality of demented patients associated with a more marked impairment of the left hemisphere. Our study was performed on autoptic brain tissue of 84 patients, out of which there were 25 non-demented non-psychotic controls, 50 demented patients (34 Alzheimer disease, 9 multi - infarct dementia and 7 mixed-type dementia patients) and 9 people with schizophrenia. The plana temporalia were evaluated via a new volumetric method using dental resin matter. Areas, cortical thickness and volumes of the right and left planum temporale were evaluated without normalization to brain weight in 60 patients and with normalization in 24 people. In controls, a mild right/left laterality of areas, cortical thickness and volumes was found. Moreover, in control women the areas of the left planum temporale were smaller than those observed in control men. The shifts to left/right laterality of areas and volumes were found in all demented groups. In the more numerous Alzheimer group, the change in laterality of an area was associated with a mild decrease on the right and a mild increase on the left side. In contrast, marked but only bilateral area shrinkage as well as reduced cortical thickness and brain volumes were observed in schizophrenic patients. |
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Authors:
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Petr Zach; Zdena Kristofiková; Jana Mrzílková; Emerich Majer; Pavel Selinger; Filip Spaniel; Daniela Rípová; Jana Kenney |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current Alzheimer research Volume: 6 ISSN: 1875-5828 ISO Abbreviation: - Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-09 Completed Date: 2009-05-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208441 Medline TA: Curr Alzheimer Res Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 69-76 Citation Subset: IM |
Affiliation:
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Department of Preclinical Studies, Faculty of Health and Social Studies, South Bohemian University, Czech Republic. zach.petr@post.cz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / pathology, physiopathology Anthropometry Auditory Cortex / pathology, physiopathology Autopsy Dementia / pathology*, physiopathology Dementia, Vascular / pathology, physiopathology Disease Progression Female Functional Laterality / physiology Humans Image Processing, Computer-Assisted Male Middle Aged Organ Size / physiology Pathology / methods Psychotic Disorders / pathology*, physiopathology Resins, Synthetic / diagnostic use Sex Characteristics Temporal Lobe / pathology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Resins, Synthetic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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