Document Detail


Planum temporale analysis via a new volumetric method in autoptic brains of demented and psychotic patients.
MedLine Citation:
PMID:  19199877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Investigations of alterations in brain asymmetry often focus on the planum temporale of patients with schizophrenia. Data also suggest changes in laterality of demented patients associated with a more marked impairment of the left hemisphere. Our study was performed on autoptic brain tissue of 84 patients, out of which there were 25 non-demented non-psychotic controls, 50 demented patients (34 Alzheimer disease, 9 multi - infarct dementia and 7 mixed-type dementia patients) and 9 people with schizophrenia. The plana temporalia were evaluated via a new volumetric method using dental resin matter. Areas, cortical thickness and volumes of the right and left planum temporale were evaluated without normalization to brain weight in 60 patients and with normalization in 24 people. In controls, a mild right/left laterality of areas, cortical thickness and volumes was found. Moreover, in control women the areas of the left planum temporale were smaller than those observed in control men. The shifts to left/right laterality of areas and volumes were found in all demented groups. In the more numerous Alzheimer group, the change in laterality of an area was associated with a mild decrease on the right and a mild increase on the left side. In contrast, marked but only bilateral area shrinkage as well as reduced cortical thickness and brain volumes were observed in schizophrenic patients.
Authors:
Petr Zach; Zdena Kristofiková; Jana Mrzílková; Emerich Majer; Pavel Selinger; Filip Spaniel; Daniela Rípová; Jana Kenney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current Alzheimer research     Volume:  6     ISSN:  1875-5828     ISO Abbreviation:  -     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208441     Medline TA:  Curr Alzheimer Res     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  69-76     Citation Subset:  IM    
Affiliation:
Department of Preclinical Studies, Faculty of Health and Social Studies, South Bohemian University, Czech Republic. zach.petr@post.cz
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / pathology,  physiopathology
Anthropometry
Auditory Cortex / pathology,  physiopathology
Autopsy
Dementia / pathology*,  physiopathology
Dementia, Vascular / pathology,  physiopathology
Disease Progression
Female
Functional Laterality / physiology
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Organ Size / physiology
Pathology / methods
Psychotic Disorders / pathology*,  physiopathology
Resins, Synthetic / diagnostic use
Sex Characteristics
Temporal Lobe / pathology*,  physiopathology
Chemical
Reg. No./Substance:
0/Resins, Synthetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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