| Plant virus expression vectors set the stage as production platforms for biopharmaceutical proteins. | |
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MedLine Citation:
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PMID: 22979981 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Transgenic plants present enormous potential as a cost-effective and safe platform for large-scale production of vaccines and other therapeutic proteins. A number of different technologies are under development for the production of pharmaceutical proteins from plant tissues. One method used to express high levels of protein in plants involves the employment of plant virus expression vectors. Plant virus vectors have been designed to carry vaccine epitopes as well as full therapeutic proteins such as monoclonal antibodies in plant tissue both safely and effectively. Biopharmaceuticals such as these offer enormous potential on many levels, from providing relief to those who have little access to modern medicine, to playing an active role in the battle against cancer. This review describes the current design and status of plant virus expression vectors used as production platforms for biopharmaceutical proteins. |
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Authors:
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Kathleen Laura Hefferon |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Virology Volume: 433 ISSN: 1096-0341 ISO Abbreviation: Virology Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-09-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0110674 Medline TA: Virology Country: United States |
Other Details:
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Languages: eng Pagination: 1-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada M5G 3B2. Electronic address: Kathleen.hefferon@utoronto.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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