| Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d. | |
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MedLine Citation:
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PMID: 20504972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is unclear whether plant stanols lower serum LDL-cholesterol concentrations and cholesterol-standardized fat-soluble antioxidant concentrations dose-dependently when consumption exceeds the recommended daily intakes of 2.0-3.0 g. OBJECTIVE: The objective was to study the relation between plant stanols provided as plant stanol esters on changes in serum concentrations of LDL cholesterol and fat-soluble antioxidants. DESIGN: Healthy subjects (n = 93) with slightly elevated serum total cholesterol concentrations (5.0-8.0 mmol/L) received, after a 3-wk run-in period, control products (n = 22) or products (margarine and soy-based yogurt) providing 3 g (n = 24), 6 g (n = 22), or 9 g (n = 25) plant stanols provided as fatty acid esters for 4 wk. RESULTS: Serum LDL cholesterol decreased dose-dependently. Compared with control, decreases in the 3-g group were 0.32 mmol/L (7.4%; P = 0.005 after adjustment for multiple comparisons). An intake of 6 g plant stanols caused an additional decrease of 0.18 mmol/L (4.5%; P = 0.100 compared with the 3-g group). In the 9-g group, a further decrease of 0.22 mmol/L (5.4%) was observed (P = 0.048 compared with the 6-g group). Serum LDL-cholesterol concentrations were lowered by 17.4% in the 9-g group compared with the control group. No effects on cholesterol-standardized beta-carotene concentrations were observed. Even the change of -0.01 mumol/mmol cholesterol (or -9.2%; P = 0.341) in the 3-g group compared with the control group was not statistically significant because of the large variation in response. Serum HDL-cholesterol and triacylglycerol concentrations, cholesterol-standardized alpha-tocopherol and lutein concentrations, and plasma markers reflecting liver and renal function were not affected. CONCLUSIONS: Daily consumption of plant stanols up to 9 g reduces serum LDL-cholesterol concentrations linearly up to 17.4%. For cholesterol-standardized fat-soluble antioxidant concentrations, such a relation could not be ascertained. |
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Authors:
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Ronald P Mensink; Arienne de Jong; Dieter Lütjohann; Guido Rmm Haenen; Jogchum Plat |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-26 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2010-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 24-33 Citation Subset: AIM; IM |
Affiliation:
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Department of Human Biology, Maastricht University, Maastricht, Netherlands. r.mensink@hb.unimaas.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Body Mass Index Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood*, drug effects Female Humans Hypercholesterolemia / blood Lipids / blood Lipoproteins / blood*, drug effects Male Margarine Middle Aged Reference Values Sitosterols / pharmacology*, therapeutic use Triglycerides / blood Yogurt |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/Lipoproteins; 0/Sitosterols; 0/Triglycerides; 57-88-5/Cholesterol; 8029-82-1/Margarine |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 2010 Jul;92(1):3-4
[PMID:
20519556
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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