Document Detail

Plant non-specific lipid transfer proteins: an interface between plant defence and human allergy.
MedLine Citation:
PMID:  17349819     Owner:  NLM     Status:  MEDLINE    
Plant non-specific LTPs (lipid transfer proteins) form a protein family of basic polypeptides of 9 kDa ubiquitously distributed throughout the plant kingdom. The members of this family are located extracellularly, usually associated with plant cell walls, and possess a broad lipid-binding specificity closely related to their three-dimensional structure. The nsLTP fold is characterized by a compact domain composed of 4 alpha-helices, firmly held by a network of 4 conserved disulphide bridges. This fold presents a large internal tunnel-like cavity, which can accommodate different types of lipids. nsLTPs are involved in plant defence mechanisms against phytopathogenic bacteria and fungi, and, possibly, in the assembly of hydrophobic protective layers of surface polymers, such as cutin. In addition, several members of the nsLTP family have been identified as relevant allergens in plant foods and pollens. Their high resistance to both heat treatment and digestive proteolytic attack has been related with the induction by these allergens of severe symptoms in many patients. Therefore, they are probably primary sensitizers by the oral route. nsLTP sensitization shows an unexpected pattern throughout Europe, with a high prevalence in the Mediterranean area, but a low incidence in Northern and Central European countries.
G Salcedo; R Sánchez-Monge; D Barber; A Díaz-Perales
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-01-08
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1771     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-11     Completed Date:  2007-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  781-91     Citation Subset:  IM    
Unidad de Bioquímica, Departamento de Biotecnología, E.T.S. Ingenieros Agrónomos, UPM, Ciudad Universitaria, 28040-Madrid, Spain.
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MeSH Terms
Allergens / immunology*
Amino Acid Sequence / genetics
Antigens, Plant / immunology*
Carrier Proteins / immunology*
Food Hypersensitivity / immunology*
Models, Molecular
Plant Proteins / immunology*
Plants / immunology*
Pollen / immunology*
Protein Conformation
Rhinitis, Allergic, Seasonal / immunology*
Sequence Alignment
Reg. No./Substance:
0/Allergens; 0/Antigens, Plant; 0/Carrier Proteins; 0/Plant Proteins; 0/lipid transfer proteins, plant

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