| Plant histaminase as an investigational drug in splanchnic artery occlusion and reperfusion. | |
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MedLine Citation:
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PMID: 18616412 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Amine oxidases are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper amine oxidases catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine and histamine. OBJECTIVE: In the present review the effects of a plant amine oxidase (histaminase, EC1.4.3.6), purified from pea seedlings, in the prevention of splanchnic postischemic reperfusion damage are reported. CONCLUSION: Various studies have clearly indicated that the use of histaminase will offer a good perspective for a novel therapeutic approach in the medical treatment of intestinal ischemia. |
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Authors:
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Salvatore Cuzzocrea; Emanuela Masini |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Expert opinion on investigational drugs Volume: 17 ISSN: 1744-7658 ISO Abbreviation: Expert Opin Investig Drugs Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-11 Completed Date: 2008-09-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434197 Medline TA: Expert Opin Investig Drugs Country: England |
Other Details:
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Languages: eng Pagination: 1151-60 Citation Subset: IM |
Affiliation:
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University of Messina, School of Medicine, Department of Clinical, Experimental Medicine and Pharmacology, Torre Biologica-Policlinico Universitario, Via Consolare Valeria-Gazzi, 98100 Messina, Italy. salvator@unime.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amine Oxidase (Copper-Containing)
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isolation & purification,
pharmacology,
therapeutic use* Animals Arterial Occlusive Diseases / drug therapy*, metabolism Drugs, Investigational / isolation & purification, pharmacology, therapeutic use* Histamine / metabolism Humans Peas / enzymology* Reactive Oxygen Species / metabolism Reperfusion Injury / drug therapy*, metabolism Seeds / enzymology Splanchnic Circulation |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Investigational; 0/Reactive Oxygen Species; 51-45-6/Histamine; EC 1.4.3.6/Amine Oxidase (Copper-Containing) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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