Document Detail

Plant derived omega-3-fatty acids protect mitochondrial function in the brain.
MedLine Citation:
PMID:  20079842     Owner:  NLM     Status:  MEDLINE    
Perilla frutescens seed oil (PFSO) represents a rich source of unsaturated fatty acids, especially of omega-3 linolenic acid and is commonly used as herbal food supplement with beneficial effects on the vascular system. The present study investigated the effects of PFSO on the central nervous system (CNS) and provides new insight into potential mechanisms for protective properties of unsaturated fatty acids within the CNS. PFSO was administered chronically to guinea pigs and neuroprotective properties were assessed ex vivo in dissociated brain cells. Dissociated brain cells isolated from PFSO treated guinea pigs were less vulnerable against nitrosative stress as indicated by decreased levels of reactive oxygen species, by stabilized mitochondrial membrane potential and enhanced levels of adenosine-triphosphate. In the brain, levels of oleic, linoleic, arachidonic and docosahexaenoic acids were significantly enhanced. However, fatty acid composition and membrane dynamics of isolated synaptosomal plasma membranes were not affected. Our findings provide new insights into the potential mechanisms for the neuroprotective actions of unsaturated fatty acids and identified PFSO as promising nutraceutical and possible alternative to fish oil supplements to provide healthful activities in the brain.
Gunter P Eckert; Cornelia Franke; Michael Nöldner; Oliver Rau; Mario Wurglics; Manfred Schubert-Zsilavecz; Walter E Müller
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-01-15
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  61     ISSN:  1096-1186     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  234-41     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Ltd. All rights reserved.
Department of Pharmacology, Campus Riedberg, Biocenter, University of Frankfurt, Germany.
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MeSH Terms
Brain Chemistry / drug effects,  physiology*
Fatty Acids, Omega-3 / administration & dosage*,  isolation & purification
Guinea Pigs
Mitochondria / drug effects,  physiology*
Neuroprotective Agents / administration & dosage*,  isolation & purification
Perilla frutescens*
Plant Oils / administration & dosage,  isolation & purification
alpha-Linolenic Acid / administration & dosage*,  isolation & purification
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Neuroprotective Agents; 0/Plant Oils; 463-40-1/alpha-Linolenic Acid; 68132-21-8/perilla seed oil

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