Document Detail


Plant antibodies for immunotherapy.
MedLine Citation:
PMID:  7480334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The original report of Hiatt (1989) initiated a wave of excitement at the realization that a complex mammalian protein such as immunoglobulin could be assembled within a plant cell. The general reaction was one of amazement, but interest in exploiting the possibilities arising from the discovery, for example to make antibodies of therapeutic value, has taken a considerable time to develop. In the meantime, other recombinant expression systems and traditional cell culture techniques have advanced and overcome some of their problems, particularly those associated with yields. Plants, however, still offer unique advantages, especially in their ability to match the protein assembly capabilities of mammalian cells (as demonstrated by the assembly of SIgA molecules), as well as to provide antibodies in bulk at low cost. In addition, the area of "immunization" of plants holds great promise and will surely be a field of enormous growth for the future.
Authors:
J K Ma; M B Hein
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Plant physiology     Volume:  109     ISSN:  0032-0889     ISO Abbreviation:  Plant Physiol.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-12-18     Completed Date:  1995-12-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0401224     Medline TA:  Plant Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  341-6     Citation Subset:  IM    
Affiliation:
Department of Immunology, United Medical School, Guy's Hospital, London, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Formation
Humans
Immunoglobulin A / biosynthesis
Immunoglobulin G / biosynthesis
Immunoglobulins / biosynthesis*
Immunotherapy*
Mammals
Plants, Genetically Modified*
Recombinant Proteins / biosynthesis*
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulins; 0/Recombinant Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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