Document Detail

Planned pregnancy in a chronic myeloid leukemia patient in molecular remission.
MedLine Citation:
PMID:  22928126     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Excellent response rates and a good quality of life have been observed since the introduction of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) treatment. Consequently, some challenges began to appear in CML women in child-bearing age wishing to become pregnant. Currently, many women around the world are in stable major/complete molecular response MMR/CMR (MMR: <0.1% BCR-ABL/ABL and CMR: undetectable BCR-ABL mRNA by RQ-PCR transcript levels on the international scale). The condition of stable MMR/CMR is linked to a long-term virtual absence of progression to the accelerated and blastic phase and to the possibility of stopping the TKI treatment with the maintenance of a condition of CMR in a proportion of cases. Imatinib teratogenic and prescribing information prohibits the use of it during pregnancy. We describe the case of a 36-year-old female patient with CML in chronic phase who stopped imatinib after 2 years in major molecular response (MMR) to plan a pregnancy. Molecular monitoring by RQ-PCR was performed quarterly. She achieved a safe pregnancy and delivery maintaining an optimal molecular response throughout the pregnancy. Isolated literature reports have been described, but no formal advice has been described at present time.
Carolina Pavlovsky; Isabel Giere; Germán Van Thillo
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Publication Detail:
Type:  Journal Article     Date:  2012-05-16
Journal Detail:
Title:  Case reports in hematology     Volume:  2012     ISSN:  2090-6579     ISO Abbreviation:  Case Rep Hematol     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-28     Completed Date:  2012-08-30     Revised Date:  2013-04-15    
Medline Journal Info:
Nlm Unique ID:  101576456     Medline TA:  Case Rep Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  624590     Citation Subset:  -    
FUNDALEU, Centro de Internación e Investigación Clínica Angélica Ocampo, Pte José E. Uriburu 1520, C1114AANP Buenos Aires, Argentina.
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