Document Detail


Planned vaginal birth or elective repeat caesarean: patient preference restricted cohort with nested randomised trial.
MedLine Citation:
PMID:  22427749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Uncertainty exists about benefits and harms of a planned vaginal birth after caesarean (VBAC) compared with elective repeat caesarean (ERC). We conducted a prospective restricted cohort study consisting of a patient preference cohort study, and a small nested randomised trial to compare benefits and risks of a planned ERC with planned VBAC.
METHODS AND FINDINGS: 2,345 women with one prior caesarean, eligible for VBAC at term, were recruited from 14 Australian maternity hospitals. Women were assigned by patient preference (n = 2,323) or randomisation (n = 22) to planned VBAC (1,225 patient preference, 12 randomised) or planned ERC (1,098 patient preference, ten randomised). The primary outcome was risk of fetal death or death of liveborn infant before discharge or serious infant outcome. Data were analysed for the 2,345 women (100%) and infants enrolled. The risk of fetal death or liveborn infant death prior to discharge or serious infant outcome was significantly lower for infants born in the planned ERC group compared with infants in the planned VBAC group (0.9% versus 2.4%; relative risk [RR] 0.39; 95% CI 0.19-0.80; number needed to treat to benefit 66; 95% CI 40-200). Fewer women in the planned ERC group compared with women in the planned VBAC had a major haemorrhage (blood loss ≥ 1,500 ml and/or blood transfusion), (0.8% [9/1,108] versus 2.3% [29/1,237]; RR 0.37; 95% CI 0.17-0.80).
CONCLUSIONS: Among women with one prior caesarean, planned ERC compared with planned VBAC was associated with a lower risk of fetal and infant death or serious infant outcome. The risk of major maternal haemorrhage was reduced with no increase in maternal or perinatal complications to time of hospital discharge. Women, clinicians, and policy makers can use this information to develop health advice and make decisions about care for women who have had a previous caesarean.
TRIAL REGISTRATION: Current Controlled Trials ISRCTN53974531
Authors:
Caroline A Crowther; Jodie M Dodd; Janet E Hiller; Ross R Haslam; Jeffrey S Robinson;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-03-13
Journal Detail:
Title:  PLoS medicine     Volume:  9     ISSN:  1549-1676     ISO Abbreviation:  PLoS Med.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-19     Completed Date:  2012-07-16     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101231360     Medline TA:  PLoS Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1001192     Citation Subset:  IM    
Affiliation:
Australian Research Centre for Health of Women and Babies (ARCH), The Discipline of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, South Australia, Australia. caroline.crowther@adelaide.edu.au
Data Bank Information
Bank Name/Acc. No.:
ISRCTN/ISRCTN53974531
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MeSH Terms
Descriptor/Qualifier:
Cesarean Section, Repeat / adverse effects*
Cohort Studies
Female
Fetal Death
Humans
Patient Preference
Pregnancy
Pregnancy Complications
Prospective Studies
Vaginal Birth after Cesarean / adverse effects*
Investigator
Investigator/Affiliation:
T Y Khong / ; J E Hiller / ; R Alexander / ; L Cochrane / ; M Ratnapala / ; S Rehman / ; G Dekker / ; S Kennedy-Andrews / ; C Pawley / ; J Hillen / ; G Matthews / ; J Sieben / ; C Dunn / ; M Mongelli / ; M Peek / ; S Sellar / ; A McCartney / ; M Shallcross / ; A Stamatiou / ; J Milligan / ; J Morris / ; S Nettleton / ; K Rickard / ; A Child / ; H Phipps / ; J Ludlow / ; E Olive / ; P Devenish-Meares / ; V Flenady / ; M Jell / ; S Jenkins-Manning / ; J MacPhail / ; Y Chadha / ; R Heath / ; M Pritchard / ; M Cram / ; L Kornman / ; S Oldfield / ; C Boniface / ; S Campbell / ; A Contarino / ; E Green / ; A Lawrence / ; D Watson / ; M Cybulski / ; K Mahomed / ; J Thomae / ; V Volobuev / ; C Compton / ; D Fleming / ; T McGee / ; D Wilton / ; S Agett / ; B Antonas / ; P Ashwood / ; V Ball / ; H Campbell / ; C A Crowther / ; H Dent / ; A Deussen / ; J M Dodd / ; L Evele / ; M Ewens / ; K Henderson / ; J E Hiller / ; C Holst / ; Y Khong / ; D McCormack / ; P Muller / ; H Oakey / ; E Pearce / ; B Peat / ; J S Robinson / ; K Robinson / ; S Russell / ; J Svigos / ; R Sweet / ; J Thomas / ; N Thomas / ; C Wilkinson / ; K Willson /
Comments/Corrections
Comment In:
Birth. 2012 Dec;39(4):333-7   [PMID:  23281956 ]
PLoS Med. 2012;9(3):e1001197   [PMID:  22479157 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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