Document Detail


Planned Parenthood experience with triphasil.
MedLine Citation:
PMID:  3656299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Triphasil, a low-dose combination oral contraceptive containing levonorgestrel and ethinyl estradiol, was tested in four Planned Parenthood clinics on 317 women between 18 and 34 years of age (mean, 23) for a total of 4,692 cycles, or 361 woman-years of usage. Approximately half these volunteers (165) were nulligravidas, and 309 (97.5%) were white. Despite instructions on proper tablet usage, there were 416 cycles (8.9%) in which one or more tablets were missed. Only one pregnancy occurred, in a cycle in which a total of four tablets was missed, for an uncorrected Pearl index of 0.28 pregnancies per 100 woman-years of usage. No pregnancy resulted from method failure, indicating a 100% efficacy rate for Triphasil when taken properly. The mean length of the menstrual cycle with Triphasil was 27.9 days; the mean length of menses, 4.4 days; and the mean latency period, 2.1 days. Menstrual flow was average in 64.1% of the subjects, light in 34.1%, heavy in 1.3% and variable in 0.5%. Amenorrhea during the tablet-free interval occurred in only 0.6% of the 4,692 cycles in which Triphasil was used. Breakthrough bleeding occurred in 6.9% of first cycles and 3.2% of total cycles; spotting, in 10.7% of first cycles and 4.4% of total cycles. Other symptoms that occurred with an incidence of greater than or equal to 1% were acne (1.0%), appetite increase (1.2%), breast discomfort (2.8%), breast enlargement (1.3%), gastrointestinal symptoms (1.7%), simple headache (1.4%) and nausea (1.1%). A total of 44 women (13.9%) discontinued treatment for medical reasons.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
M S Hanson; G K Stewart; R C Bechtel; E S Turan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  32     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-11-16     Completed Date:  1987-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  592-6     Citation Subset:  IM; J    
Affiliation:
Planned Parenthood of Minnesota, Minneapolis 55404.
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MeSH Terms
Descriptor/Qualifier:
Adult
Contraceptives, Oral, Synthetic*
Drug Tolerance
Ethinyl Estradiol*
Ethinyl Estradiol-Norgestrel Combination
Family Planning Services*
Female
Humans
Menstrual Cycle / drug effects
Norgestrel*
Patient Compliance
Pregnancy
Chemical
Reg. No./Substance:
0/Contraceptives, Oral, Synthetic; 57-63-6/Ethinyl Estradiol; 6533-00-2/Norgestrel; 8056-51-7/Ethinyl Estradiol-Norgestrel Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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