Document Detail


Planarian fibroblast growth factor receptor homologs expressed in stem cells and cephalic ganglions.
MedLine Citation:
PMID:  12060069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The strong regenerative capacity of planarians is considered to reside in the totipotent somatic stem cell called the 'neoblast'. However, the signal systems regulating the differentiation/growth/migration of stem cells remain unclear. The fibroblast growth factor (FGF)/FGF receptor (FGFR) system is thought to mediate various developmental events in both vertebrates and invertebrates. We examined the molecular structures and expression of DjFGFR1 and DjFGFR2, two planarian genes closely related to other animal FGFR genes. DjFGFR1 and DjFGFR2 proteins contain three and two immunoglobulin-like domains, respectively, in the extracellular region and a split tyrosine kinase domain in the intracellular region. Expression of DjFGFR1 and DjFGFR2 was observed in the cephalic ganglion and mesenchymal space in intact planarians. In regenerating planarians, accumulation of DjFGFR1-expressing cells was observed in the blastema and in fragments regenerating either a pharynx or a brain. In X-ray-irradiated planarians, which had lost regenerative capacity, the number of DjFGFR1-expressing cells in the mesenchymal space decreased markedly. These results suggest that the DjFGFR1 protein may be involved in the signal systems controlling such aspects of planarian regeneration as differentiation/growth/migration of stem cells.
Authors:
Kazuya Ogawa; Chiyoko Kobayashi; Tetsutaro Hayashi; Hidefumi Orii; Kenji Watanabe; Kiyokazu Agata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development, growth & differentiation     Volume:  44     ISSN:  0012-1592     ISO Abbreviation:  Dev. Growth Differ.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-12     Completed Date:  2003-08-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0356504     Medline TA:  Dev Growth Differ     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  191-204     Citation Subset:  IM    
Affiliation:
Laboratory of Regeneration Biology, Department of Life Science, Faculty of Science, Himeji Institute of Technology, Harima Science Garden City, Akou, Hyogo 678-1297, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
DNA, Helminth
Ganglia, Invertebrate / metabolism*
Gene Expression Profiling
Molecular Sequence Data
Planarians / genetics*,  metabolism,  radiation effects
Protein Structure, Tertiary
RNA Interference
Receptor Protein-Tyrosine Kinases / genetics*,  metabolism,  radiation effects
Receptor, Fibroblast Growth Factor, Type 1
Receptor, Fibroblast Growth Factor, Type 2
Receptors, Fibroblast Growth Factor / genetics*,  metabolism,  radiation effects
Regeneration / genetics
Stem Cells / metabolism*
X-Rays
Chemical
Reg. No./Substance:
0/DNA, Helminth; 0/Receptors, Fibroblast Growth Factor; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases; EC 2.7.10.1/Receptor, Fibroblast Growth Factor, Type 1; EC 2.7.10.1/Receptor, Fibroblast Growth Factor, Type 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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