Document Detail


Planar myocardial perfusion imaging with technetium-99m-teboroxime: comparison by vascular territory with thallium-201 and coronary angiography.
MedLine Citation:
PMID:  1403145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial perfusion agents labeled with 99mTc offer improved physical imaging properties compared to 201TI. Teboroxime is a new 99mTc-labeled compound for myocardial perfusion imaging that shows a high myocardial extraction and rapid clearance. Sixty-seven patients underwent planar teboroxime imaging with a rapid acquisition protocol. Agreement of teboroxime and 201TI for the presence or absence of disease occurred in 56/65 patients (86%). There was agreement (normal or abnormal) between the two agents in 156/195 vessels (80%) and 457/585 segments (78%). When abnormal segments (ischemia or infarction) were compared, teboroxime showed significantly more ischemic segments (89/135, 66%) than did 201TI (73/135, 54%, p < 0.05). Teboroxime offers accuracy comparable to 201TI for the diagnosis of coronary artery disease and may improve the detection of ischemic or viable myocardium. In addition, its rapid myocardial clearance permits stress/rest imaging in 60-90 min.
Authors:
S T Dahlberg; H Weinstein; R C Hendel; B McSherry; J A Leppo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  33     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-19     Completed Date:  1992-11-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1783-8     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, University of Massachusetts Medical Center, Worcester 01655.
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MeSH Terms
Descriptor/Qualifier:
Coronary Angiography
Coronary Disease / radiography,  radionuclide imaging*
Evaluation Studies as Topic
Exercise Test
Female
Heart / radionuclide imaging*
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Organotechnetium Compounds / diagnostic use*
Oximes / diagnostic use*
Sensitivity and Specificity
Thallium Radioisotopes / diagnostic use
Time Factors
Grant Support
ID/Acronym/Agency:
HL34199/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Oximes; 0/Thallium Radioisotopes; 104716-22-5/technetium Tc 99m teboroxime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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