Document Detail


Planar cell polarity signaling in craniofacial development.
MedLine Citation:
PMID:  22134372     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity within the epithelial cells of the Drosophila wing, has been linked to the proper development of a wide variety of tissues in vertebrates and invertebrates. While many of the pathway members are conserved, it appears that some of the members of the pathway act in a tissue-specific manner. Here, we discuss the role of this pathway in vertebrate craniofacial development, highlighting cranial neural crest migration, skull and palate formation and the role of non-traditional modulators of PCP signaling within this developmental process.
Authors:
Jacek Topczewski; Rodney M Dale; Barbara E Sisson
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-10-01
Journal Detail:
Title:  Organogenesis     Volume:  7     ISSN:  1555-8592     ISO Abbreviation:  Organogenesis     Publication Date:    2011 Oct-Dec
Date Detail:
Created Date:  2011-12-26     Completed Date:  2012-08-08     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101253266     Medline TA:  Organogenesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255-9     Citation Subset:  IM    
Affiliation:
Northwestern University, Feinberg School of Medicine, Department of Pediatrics, Children’s Memorial Research Center, Chicago, IL, USA. j-topczewski@northwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Polarity*
Face / embryology*
Neural Crest / cytology
Signal Transduction*
Skull / cytology*,  embryology*
Wnt Proteins / metabolism
Grant Support
ID/Acronym/Agency:
F32DE019058/DE/NIDCR NIH HHS; F32DE019986/DE/NIDCR NIH HHS; R01DE016678/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Wnt Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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