Document Detail


Planar cell polarity signaling in the Drosophila eye.
MedLine Citation:
PMID:  20959167     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Planar cell polarity (PCP) signaling regulates the establishment of polarity within the plane of an epithelium and allows cells to obtain directional information. Its results are as diverse as the determination of cell fates, the generation of asymmetric but highly aligned structures (e.g., stereocilia in the human ear or hairs on a fly wing), or the directional migration of cells during convergent extension during vertebrate gastrulation. Aberrant PCP establishment can lead to human birth defects or kidney disease. PCP signaling is governed by the noncanonical Wnt or Fz/PCP pathway. Traditionally, PCP establishment has been best studied in Drosophila, mainly due to the versatility of the fly as a genetic model system. In Drosophila, PCP is essential for the orientation of wing and abdominal hairs, the orientation of the division axis of sensory organ precursors, and the polarization of ommatidia in the eye, the latter requiring a highly coordinated movement of groups of photoreceptor cells during the process of ommatidial rotation. Here, I review our current understanding of PCP signaling in the Drosophila eye and allude to parallels in vertebrates.
Authors:
Andreas Jenny
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current topics in developmental biology     Volume:  93     ISSN:  1557-8933     ISO Abbreviation:  Curr. Top. Dev. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-20     Completed Date:  2011-01-26     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0163114     Medline TA:  Curr Top Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  189-227     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Polarity / physiology*
Cytoskeleton / metabolism
Drosophila Proteins / genetics,  metabolism
Drosophila melanogaster / anatomy & histology*,  physiology
Humans
Morphogenesis / physiology
Photoreceptor Cells, Invertebrate / cytology,  physiology
Signal Transduction / physiology*
Grant Support
ID/Acronym/Agency:
1R01GM088202/GM/NIGMS NIH HHS; R01 GM088202/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins

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