| Planar cell polarity: keeping hairs straight is not so simple. | |
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MedLine Citation:
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PMID: 20182624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fur on a cat's back, the scales on a fish, or the bristles on a fly are all beautifully organized, with a high degree of polarization in their surface organization. Great progress has been made in understanding how individual cell polarity is established, but our understanding of how cells coordinate their polarity in forming coherent tissues is still fragmentary. The organization of cells in the plane of the epithelium is known as planar cell polarity (PCP), and studies in the past decade have delineated a genetic pathway for the control of PCP. This review will first briefly review data from the Drosophila field, where PCP was first identified and genetically characterized, and then explore how vertebrate tissues become polarized during development. |
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Authors:
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Helen McNeill |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cold Spring Harbor perspectives in biology Volume: 2 ISSN: 1943-0264 ISO Abbreviation: Cold Spring Harb Perspect Biol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-25 Completed Date: 2010-09-28 Revised Date: 2010-09-30 |
Medline Journal Info:
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Nlm Unique ID: 101513680 Medline TA: Cold Spring Harb Perspect Biol Country: United States |
Other Details:
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Languages: eng Pagination: a003376 Citation Subset: IM |
Affiliation:
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Samuel Lunenfeld Research Institute, Department of Molecular Genetics, University of Toronto, Toronto, Canada. mcneill@mshri.on.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning Cell Polarity* Drosophila melanogaster Epithelium / metabolism* Gene Expression Regulation, Developmental Hair / physiology Humans Kidney Diseases, Cystic / metabolism Mice Models, Biological Mutation Phenotype |
| Comments/Corrections | |
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