Document Detail

Planar cell polarity in kidney development and disease.
MedLine Citation:
PMID:  22027435     Owner:  NLM     Status:  MEDLINE    
Planar cell polarity (PCP) describes the coordinated polarization of tissue cells in a direction that is orthogonal to their apical/basal axis. In the last several years, studies in flies and vertebrates have defined evolutionarily conserved pathways that establish and maintain PCP in various cellular contexts. Defective responses to the polarizing signal(s) have deleterious effects on the development and repair of a wide variety of organs/tissues. In this review, we cover the known and hypothesized roles for PCP in the metanephric kidney. We highlight the similarities and differences in PCP establishment in this organ compared with flies, especially the role of Wnt signaling in this process. Finally, we present a model whereby the signal(s) that organizes PCP in the kidney epithelium, at least in part, comes from the adjacent stromal fibroblasts.
Thomas J Carroll; Amrita Das
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-07-01
Journal Detail:
Title:  Organogenesis     Volume:  7     ISSN:  1555-8592     ISO Abbreviation:  Organogenesis     Publication Date:    2011 Jul-Sep
Date Detail:
Created Date:  2011-11-21     Completed Date:  2012-07-09     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101253266     Medline TA:  Organogenesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  180-90     Citation Subset:  IM    
Department of Internal Medicine (Nephrology), University of Texas Southwestern Medical Center, Dallas, TX, USA.
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MeSH Terms
Cell Polarity / physiology*
Diptera / cytology
Epithelial Cells / metabolism
Kidney / cytology*,  embryology,  metabolism
Kidney Diseases, Cystic / metabolism,  pathology*
Signal Transduction / physiology
Wnt Proteins / metabolism,  physiology
Grant Support
Reg. No./Substance:
0/Wnt Proteins

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