Document Detail


Planar bilayer membranes from pure lipids.
MedLine Citation:
PMID:  497184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Planar lipid bilayer membranes are formed from mixtures of pure lipids in the absence of non-biological solvents. The solventless bilayers are characterized by a large specific capacitance (586-957 nF/cm2) comparable to that of cell membranes but considerably greater than that of conventional lipid/decane bilayers. Hydrocarbon solvents, such as n-alkanes or squalene, thicken the bilayer. Membrane dielectric thickness is used as an indicator of bilayer lipid composition. For membranes made from pure monoglyceride/triglyceride mixtures the thickness of the solventless lipid bilayer is independent of both the chain length (11-22 carbons) and mol fraction (0.1-0.9) of triglyceride in the bulk mixture. In contrast, the thickness of the bilayer (2.0-3.3 nm) depends strongly upon the length (16-24 carbons) of the monoglyceride component. Molecular volume considerations lead to the conclusion that the bulk lipid mixture disproportionates to yield bilayer membranes composed of nearly pure monoglyceride. The dielectric thickness of the monoglyceride bilayer is consistent with the notion that the lipid fatty acyl chains are fluid.
Authors:
R C Waldbillig; G Szabo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  557     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-01-24     Completed Date:  1980-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  295-305     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Glycerides
Hydrocarbons
Lipid Bilayers*
Solvents
Thermodynamics
Chemical
Reg. No./Substance:
0/Glycerides; 0/Hydrocarbons; 0/Lipid Bilayers; 0/Solvents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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