Document Detail

Planar biaxial characterization of diseased human coronary and carotid arteries for computational modeling.
MedLine Citation:
PMID:  22236530     Owner:  NLM     Status:  MEDLINE    
Computational models have the potential to provide precise estimates of stresses and strains associated with sites of coronary plaque rupture. However, lack of adequate mathematical description of diseased human vessel wall mechanical properties is hindering computational accuracy. The goal of this study is to characterize the behavior of diseased human coronary and carotid arteries using planar biaxial testing. Diseased coronary specimens exhibit relatively high stiffness (50-210 kPa) and low extensibility (1-10%) at maximum equibiaxial stress (250 kPa) compared to human carotid specimens and values commonly reported for porcine coronary arteries. A thick neointimal layer observed histologically appears to be associated with heightened stiffness and the direction of anisotropy of the specimens. Fung, Choi-Vito and modified Mooney-Rivlin constitutive equations fit the multiaxial data from multiple stress protocols well, and parameters from representative coronary specimens were utilized in a finite element model with fluid-solid interactions. Computed locations of maximal stress and strain are substantially altered, and magnitudes of maximum principal stress (48-65 kPa) and strain (6.5-8%) in the vessel wall are lower than previously predicted using parameters from uniaxial tests. Taken together, the results demonstrate the importance of utilizing disease-matched multiaxial constitutive relationships within patient-specific computational models to accurately predict stress and strain within diseased coronary arteries.
Mehmet H Kural; Mingchao Cai; Dalin Tang; Tracy Gwyther; Jie Zheng; Kristen L Billiar
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-10
Journal Detail:
Title:  Journal of biomechanics     Volume:  45     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-05     Completed Date:  2012-09-11     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  790-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Aged, 80 and over
Biomechanical Phenomena / physiology
Carotid Arteries / pathology*
Computer Simulation
Coronary Artery Disease / pathology*
Coronary Vessels / pathology*
Middle Aged
Models, Cardiovascular*
Grant Support
R01 EB004759/EB/NIBIB NIH HHS; R01 EB004759-05/EB/NIBIB NIH HHS; R01 EB004759-06/EB/NIBIB NIH HHS; R01 EB004759-07/EB/NIBIB NIH HHS; R01 EB004759-08/EB/NIBIB NIH HHS; R01EB004759/EB/NIBIB NIH HHS

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