Document Detail

Planar Cell Polarity and the Developmental Control of Cell Behavior in Vertebrate Embryos.
MedLine Citation:
PMID:  22905955     Owner:  NLM     Status:  Publisher    
Planar cell polarity (PCP), the orientation and alignment of cells within a sheet, is a ubiquitous cellular property that is commonly governed by the conserved set of proteins encoded by so-called PCP genes. The PCP proteins coordinate developmental signaling cues with individual cell behaviors in a wildly diverse array of tissues. Consequently, disruptions of PCP protein functions are linked to defects in axis elongation, inner ear patterning, neural tube closure, directed ciliary beating, and left/right patterning, to name only a few. This review attempts to synthesize what is known about PCP and the PCP proteins in vertebrate animals, with a particular focus on the mechanisms by which individual cells respond to PCP cues in order to execute specific cellular behaviors. Expected final online publication date for the Annual Review of Cell and Developmental Biology Volume 28 is October 06, 2012. Please see for revised estimates.
John B Wallingford
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-16
Journal Detail:
Title:  Annual review of cell and developmental biology     Volume:  -     ISSN:  1530-8995     ISO Abbreviation:  Annu. Rev. Cell Dev. Biol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9600627     Medline TA:  Annu Rev Cell Dev Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Howard Hughes Medical Institute, Section of Molecular, Cell and Developmental Biology, and Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas, 78712; email:
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