Document Detail

Plain and buffered lidocaine for neonatal circumcision.
MedLine Citation:
PMID:  10074977     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if buffered lidocaine provided a more effective nerve block in a short time than plain lidocaine for neonatal circumcision. METHODS: One hundred ninety-four newborn males were studied in a randomized trial using two dorsal penile nerve block preparations for circumcision. Ninety-two received plain lidocaine, and 102 received buffered lidocaine. The infants were evaluated at timed intervals before the procedure, during anesthetic injection, and during circumcision. Objective measurements of heart rate and oxygen saturation, and subjective determinations of behavioral state were recorded. Using heart rate as the major outcome variable, it was determined that 65 subjects per group would be needed to achieve a power of .08. Complications also were noted. RESULTS: Heart rates and oxygen saturations were similar in the two groups at each timed interval. The behavioral characteristics and amount of crying also were comparable in both groups. The only complication was minor bleeding, seen in each group. CONCLUSION: Adding a buffering agent to lidocaine did not provide a more effective level of anesthesia in a short time.
C W Newton; N Mulnix; L Baer; T Bovee
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  93     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-05     Completed Date:  1999-04-05     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  350-2     Citation Subset:  AIM; IM    
Blodgett Memorial Medical Center, Grand Rapids, Michigan 49506, USA.
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MeSH Terms
Anesthetics, Local*
Autonomic Nerve Block
Circumcision, Male / adverse effects*
Infant, Newborn
Intraoperative Care
Pain / etiology,  prevention & control*
Reg. No./Substance:
0/Anesthetics, Local; 0/Buffers; 137-58-6/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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