| Plafibride treatment and serum lipids in hyperlipoproteinemias. | |
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MedLine Citation:
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PMID: 3323393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study was made of 26 patients suffering from primary hyperlipoproteinemia; 8 belonging to familial hypercholesterolemia (phenotype IIa), 9 to familial combined hyperlipidemia (phenotype IIb, 9 to familial hypertriglyceridemia (phenotype IV). During treatment, which was continued for two years, all patients received a diet consisting of 45% carbohydrates, 33% fats and 22% protein. They were given 400 mg (TID) of Plafibride after breakfast, lunch and dinner. In the three phenotypes studied, significant decreases in cholesterol, triglycerides, glucose, insulin and lecithin were observed, while there was an increase in HDL cholesterol, free fatty acids and lysolecithin. Tolerance to the drug was good, and a study of different serum enzymes revealed no undesirable collateral effects. |
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Authors:
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F Rodriguez; I M López; E Jover |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medicine Volume: 18 ISSN: 0025-7850 ISO Abbreviation: J Med Publication Date: 1987 |
Date Detail:
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Created Date: 1988-03-18 Completed Date: 1988-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7505566 Medline TA: J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 153-63 Citation Subset: IM |
Affiliation:
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Medical Faculty of Valladolid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Glucose Cholesterol / blood Clofibrate / analogs & derivatives* Clofibric Acid / analogs & derivatives*, therapeutic use Diet Female Humans Hyperlipoproteinemia Type II / drug therapy* Hyperlipoproteinemia Type IV / drug therapy* Insulin / blood Male Phosphatidylcholines / blood Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Phosphatidylcholines; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol; 63394-05-8/plafibride; 637-07-0/Clofibrate; 882-09-7/Clofibric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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