Document Detail

Placentomegaly with massive hydrops of placental stem villi, diploid DNA content, and fetal omphaloceles: possible association with Beckwith-Wiedemann syndrome.
MedLine Citation:
PMID:  1864589     Owner:  NLM     Status:  MEDLINE    
Marked placental hydrops is generally associated with hydatidiform mole. Diagnosis of hydatidiform mole requires both villous hydrops and trophoblast hyperplasia. This report describes four cases with massive hydrops of placental stem villi without associated trophoblast hyperplasia. All four had diploid DNA content by flow cytometry. Fetal omphalocele was present in three; and one had diagnostic Beckwith-Wiedemann syndrome (BWS). In two others, there were pathologic features suggestive of BWS. The fourth fetus had multiple anomalies by ultrasound; autopsy examination of the fragmented fetus failed to disclose additional pathology. The association of massive placental hydrops involving stem villi, fetal omphalocele, and diploid DNA content is unusual. These fetal and placental findings may suggest possible BWS in some cases and allow for antenatal diagnosis of affected fetuses, clinical evaluation of additional family members, and planning for neonatal care.
J M Lage
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human pathology     Volume:  22     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-09-06     Completed Date:  1991-09-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  591-7     Citation Subset:  IM    
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
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MeSH Terms
Beckwith-Wiedemann Syndrome / embryology,  pathology*
Chorionic Villi / pathology*
DNA / analysis
Edema / genetics,  pathology*
Fetal Diseases / pathology*
Fetus / pathology
Flow Cytometry
Hernia, Umbilical / pathology*
Placenta / pathology
Placenta Diseases / genetics,  pathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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