| Placentation, antiphospholipid syndrome and pregnancy outcome. | |
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MedLine Citation:
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PMID: 11237128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiphospholipid antibodies (aPLs) are a diverse group of autoantibodies associated with a pattern of disease known as antiphospholipid syndrome (APS). Pregnancy complications secondary to placental insufficiency are key features of this disease. The mechanisms underlying the placental pathology remain unclear. In this article the process of placentation in healthy and pathological pregnancies is reviewed. The evidence for defective placentation in APS pregnancies and involvement of aPLs in this process is summarized. Finally hypotheses based on the interpretation of these studies are discussed. |
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Authors:
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S Stone; M A Khamashta; L Poston |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Lupus Volume: 10 ISSN: 0961-2033 ISO Abbreviation: Lupus Publication Date: 2001 |
Date Detail:
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Created Date: 2001-03-09 Completed Date: 2001-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9204265 Medline TA: Lupus Country: England |
Other Details:
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Languages: eng Pagination: 67-74 Citation Subset: IM |
Affiliation:
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Lupus Pregnancy Clinic, St Thomas' Hospitals, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antiphospholipid Syndrome* Female Humans Placentation* Pregnancy Pregnancy Complications* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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