Document Detail

Placentation, antiphospholipid syndrome and pregnancy outcome.
MedLine Citation:
PMID:  11237128     Owner:  NLM     Status:  MEDLINE    
The antiphospholipid antibodies (aPLs) are a diverse group of autoantibodies associated with a pattern of disease known as antiphospholipid syndrome (APS). Pregnancy complications secondary to placental insufficiency are key features of this disease. The mechanisms underlying the placental pathology remain unclear. In this article the process of placentation in healthy and pathological pregnancies is reviewed. The evidence for defective placentation in APS pregnancies and involvement of aPLs in this process is summarized. Finally hypotheses based on the interpretation of these studies are discussed.
S Stone; M A Khamashta; L Poston
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Lupus     Volume:  10     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-09     Completed Date:  2001-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  67-74     Citation Subset:  IM    
Lupus Pregnancy Clinic, St Thomas' Hospitals, London, UK.
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MeSH Terms
Antiphospholipid Syndrome*
Pregnancy Complications*

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